Simple Summary Phosphoinositol signaling pathways and their dysregulation have been
shown to have a fundamental role in health and disease, respectively. The SH2-containing …

Abstract Phosphoinositide‐3‐kinase/AKT (PI3K/AKT) signaling plays key roles in the
regulation of cellular activity in both health and disease. In immune cells, this PI3K/AKT …

SHP2 (PTPN11) acts upstream of SOS1/2 to enable RAS activation. Allosteric SHP2
inhibitors (SHP2i) in the clinic prevent SHP2 activation, block proliferation of RTK-or cycling …

Abstract Background Prohibitin 2 (PHB2) exhibits opposite functions of promoting or
inhibiting tumour across various cancer types. In this study, we aim to investigate its …

Ebselen, a multifunctional organoselenium compound, has been recognized as a potential
treatment for diabetes-related disorders. However, the underlying mechanisms whereby …

Since the last century, when scientists proposed the lock-and-key model, the discovery of
drugs has focused on the development of drugs acting on single target. However, single …

Among the diverse protein binding modules, Sam (Sterile alpha motif) domains attract
attention due to their versatility. They are present in different organisms and play many …

Most colonial marine invertebrates are capable of allorecognition, the ability to distinguish
between themselves and conspecifics. One long-standing question is whether invertebrate …

Modulating the activity of the Src Homology 2 (SH2)—containing Inositol 5′-Phosphatase
(SHIP) enzyme family with small molecule inhibitors provides a useful and unconventional …

Abstract SHIP2 (Src homology 2 domain‐containing inositol 5′‐phosphatase 2) belongs to
the family of 5′‐phosphatases. It regulates the phosphoinositide 3‐kinase (PI3K)‐mediated …