Besides their function in limiting blood loss and promoting wound healing, experimental
evidence has highlighted platelets as active players in all steps of tumorigenesis including …

Although once primarily recognized for its roles in hemostasis and thrombosis, the platelet
has been increasingly recognized as a multipurpose cell. Indeed, circulating platelets have …

There has been remarkable insight into the importance of platelets in a wide range of
pathophysiologic events, including inflammation and cancer progression. Thrombocytosis in …

Elevated platelet counts in patients diagnosed with malignant tumors were first described
more than 100 years ago. Today it is well known that in many types of solid tumors …

Circulating, cell-free microRNAs (miRNAs) are promising candidate biomarkers, but optimal
conditions for processing blood specimens for miRNA measurement remain to be …

An association between platelets, angiogenesis, and cancer has long been recognized, but
the mechanisms linking them remains unclear. Platelets regulate new blood vessel growth …

Platelets have been hypothesized to promote certain neoplastic malignancies; however,
antiplatelet drugs are still not part of routine pharmacological cancer prevention and …

Paraneoplastic syndromes are signs or symptoms that occur as a result of organ or tissue
damage at locations remote from the site of the primary tumor or metastases. Paraneoplastic …

Current understanding of tumor immunosuppressive mechanisms forms the basis for
modern day immunotherapies. Immunoregulatory role of platelets in cancer remains largely …

Importance Individuals with cancer often have an elevated platelet count at the time of
diagnosis. The extent to which an elevated platelet count is an indicator of cancer is unclear …