B cells and tertiary lymphoid structures as determinants of tumour immune contexture and clinical outcome
B cells are a major component of the tumour microenvironment, where they are
predominantly associated with tertiary lymphoid structures (TLS). In germinal centres within …
predominantly associated with tertiary lymphoid structures (TLS). In germinal centres within …
Dendritic cell subsets in cancer immunity and tumor antigen sensing
Dendritic cells (DCs) exhibit a specialized antigen-presenting function and play crucial roles
in both innate and adaptive immune responses. Due to their ability to cross-present tumor …
in both innate and adaptive immune responses. Due to their ability to cross-present tumor …
[PDF][PDF] Vaccine-boosted CAR T crosstalk with host immunity to reject tumors with antigen heterogeneity
Chimeric antigen receptor (CAR) T cell therapy effectively treats human cancer, but the loss
of the antigen recognized by the CAR poses a major obstacle. We found that in vivo vaccine …
of the antigen recognized by the CAR poses a major obstacle. We found that in vivo vaccine …
Virus-like particles as preventive and therapeutic cancer vaccines
Virus-like particles (VLPs) are self-assembled viral protein complexes that mimic the native
virus structure without being infectious. VLPs, similarly to wild type viruses, are able to …
virus structure without being infectious. VLPs, similarly to wild type viruses, are able to …
Interventional hydrogel microsphere vaccine as an immune amplifier for activated antitumour immunity after ablation therapy
X Liu, Y Zhuang, W Huang, Z Wu, Y Chen… - Nature …, 2023 - nature.com
The response rate of pancreatic cancer to chemotherapy or immunotherapy pancreatic
cancer is low. Although minimally invasive irreversible electroporation (IRE) ablation is a …
cancer is low. Although minimally invasive irreversible electroporation (IRE) ablation is a …
Recent advances and challenges in cancer immunotherapy
C Peterson, N Denlinger, Y Yang - Cancers, 2022 - mdpi.com
Simple Summary Immunotherapy helps a person's immune system to target tumor cells.
Recent advances in cancer immunotherapy, including immune checkpoint inhibition …
Recent advances in cancer immunotherapy, including immune checkpoint inhibition …
Elastic Nanovaccine Enhances Dendritic Cell‐Mediated Tumor Immunotherapy
Nanovaccine‐based immunotherapy (NBI) has the ability to initiate dendritic cell (DC)‐
mediated tumor‐specific immune responses and maintain long‐term antitumor immune …
mediated tumor‐specific immune responses and maintain long‐term antitumor immune …
[HTML][HTML] DCs at the center of help: Origins and evolution of the three-cell-type hypothesis
Last year was the 10th anniversary of Ralph Steinman's Nobel Prize awarded for his
discovery of dendritic cells (DCs), while next year brings the 50th anniversary of that …
discovery of dendritic cells (DCs), while next year brings the 50th anniversary of that …
Immune cellular components and signaling pathways in the tumor microenvironment
During the past decade there has been a revolution in cancer therapeutics by the
emergence of antibody-based and cell-based immunotherapies that modulate immune …
emergence of antibody-based and cell-based immunotherapies that modulate immune …
[HTML][HTML] Strategies to overcome DC dysregulation in the tumor microenvironment
G Mestrallet, K Sone, N Bhardwaj - Frontiers in Immunology, 2022 - frontiersin.org
Dendritic cells (DCs) play a key role to modulate anti-cancer immunity in the tumor
microenvironment (TME). They link innate to adaptive immunity by processing and …
microenvironment (TME). They link innate to adaptive immunity by processing and …