Summary Interleukin-2 (IL-2) variants with increased CD25 dependence that selectively
expand Foxp3+ regulatory T (TR) cells are in clinical trials for treating inflammatory …

Dendritic cells (DCs) are professional antigen presenting cells that play an important role in
the induction of T cell responses. Different subsets (cDC1s, cDC2s, pDCs, and moDCs) …

Therapy-induced senescence (TIS) may contribute to therapy resistance; however, evidence
also suggests that senescent cells (SnCs) may promote anti-tumor immunity. Here, we …

Background Adjuvant therapies such as radiation therapy, chemotherapy, and
immunotherapy are usually given after cancer surgery to improve the survival of cancer …

Simple Summary Although the immune system can mount effective responses against
antigens within the CNS, this does not occur in the context of high-grade gliomas …

Virus-like particles (VLPs) are self-assembled viral protein complexes that mimic the native
virus structure without being infectious. VLPs, similarly to wild type viruses, are able to …

In the present study, for the first time, we released and assembled the particles of three
major structural proteins of velogenic NDV (M, HN, and F glycoproteins) as a NDV-VLPs …

Breast cancer brain metastases (BCBM) are a significant cause of mortality and are
incurable. Thus, identifying BCBM targets that reduce morbidity and mortality is critical …

BACKGROUND Mitophagy plays essential role in the development and progression of
colorectal cancer (CRC). However, the effect of mitophagy-related genes in CRC remains …

Despite the important breakthroughs of immune-checkpoint inhibitors (ICIs) in recent years,
the overall objective response rate (ORR) remains limited in various cancers. Here, we …