Adenosine A2A receptor antagonists: from caffeine to selective non‐xanthines
KA Jacobson, ZG Gao, P Matricon… - British journal of …, 2022 - Wiley Online Library
A long evolution of knowledge of the psychostimulant caffeine led in the 1960s to another
purine natural product, adenosine and its A2A receptor. Adenosine is a short‐lived …
purine natural product, adenosine and its A2A receptor. Adenosine is a short‐lived …
The role of adenosine A2A receptors in Alzheimer's disease and tauopathies
A Launay, O Nebie, JV Shankara, T Lebouvier… - …, 2023 - Elsevier
Adenosine signals through four distinct G protein-coupled receptors that are located at
various synapses, cell types and brain areas. Through them, adenosine regulates …
various synapses, cell types and brain areas. Through them, adenosine regulates …
Potentiation of cannabinoid signaling in microglia by adenosine A2A receptor antagonists
R Franco, I Reyes‐Resina, D Aguinaga, A Lillo… - Glia, 2019 - Wiley Online Library
Neuroprotective M2‐skewed microglia appear as promising to alter the course of
neurodegenerative diseases and G protein‐coupled receptors (GPCRs) are potential targets …
neurodegenerative diseases and G protein‐coupled receptors (GPCRs) are potential targets …
Oligomeric receptor complexes and their allosteric receptor-receptor interactions in the plasma membrane represent a new biological principle for integration of …
DO Borroto-Escuela, K Fuxe - Frontiers in molecular neuroscience, 2019 - frontiersin.org
G protein-coupled receptors (GPCRs) not only exist as monomers but also as homomers
and heteromers in which allosteric receptor-receptor interactions take place, modulating the …
and heteromers in which allosteric receptor-receptor interactions take place, modulating the …
Hopf bifurcation mechanism analysis in an improved cortex-basal ganglia network with distributed delays: An application to Parkinson's disease
Z Wang, B Hu, W Zhou, M Xu, D Wang - Chaos, Solitons & Fractals, 2023 - Elsevier
In this paper, we introduce general distributed delays (in pathways between different
neurons) and self-feedback distributed delays (in self-feedback pathways) into an improved …
neurons) and self-feedback distributed delays (in self-feedback pathways) into an improved …
Dysfunctional heteroreceptor complexes as novel targets for the treatment of major depressive and anxiety disorders
M Pérez de la Mora, DO Borroto-Escuela… - Cells, 2022 - mdpi.com
Among mental diseases, major depressive disorder (MDD) and anxiety deserve a special
place due to their high prevalence and their negative impact both on society and patients …
place due to their high prevalence and their negative impact both on society and patients …
Adenosinergic pathway in Parkinson's disease: Recent advances and therapeutic perspective
Y Zhao, X Liu, G Yang - Molecular Neurobiology, 2023 - Springer
Parkinson's disease (PD) is a neurodegenerative disease characterized pathologically by α-
synuclein (α-syn) aggregation. In PD, the current mainstay of symptomatic treatment is …
synuclein (α-syn) aggregation. In PD, the current mainstay of symptomatic treatment is …
[HTML][HTML] Computational Studies Applied to Linalool and Citronellal Derivatives Against Alzheimer's and Parkinson's Disorders: A Review with Experimental Approach
PR da Silva, JC de Andrade, NF de Sousa… - Current …, 2023 - ncbi.nlm.nih.gov
Alzheimer's and Parkinson's are neurodegenerative disorders that affect a great number of
people around the world, seriously compromising the quality of life of individuals, due to …
people around the world, seriously compromising the quality of life of individuals, due to …
Adenosine-related mechanisms in non-adenosine receptor drugs
KA Jacobson, ML Reitman - Cells, 2020 - mdpi.com
Many ligands directly target adenosine receptors (ARs). Here we review the effects of
noncanonical AR drugs on adenosinergic signaling. Non-AR mechanisms include raising …
noncanonical AR drugs on adenosinergic signaling. Non-AR mechanisms include raising …
[HTML][HTML] Boolean analysis shows a high proportion of dopamine D2 receptors interacting with adenosine A2A receptors in striatal medium spiny neurons of mouse and …
R Rivas-Santisteban, AJ Rico, A Muñoz… - Neurobiology of …, 2023 - Elsevier
The antagonistic effect of adenosine on dopaminergic transmission in the basal ganglia
indirect motor control pathway is mediated by dopamine D 2 (D 2 R) and adenosine A 2A (A …
indirect motor control pathway is mediated by dopamine D 2 (D 2 R) and adenosine A 2A (A …