Copper homeostasis is strictly regulated by protein transporters and chaperones, to allow its
correct distribution and avoid uncontrolled redox reactions. Several studies address copper …

Wilson disease (WD) is a potentially treatable, inherited disorder of copper metabolism that
is characterized by the pathological accumulation of copper. WD is caused by mutations in …

Copper is an essential metal required for many metalloproteins' function. A fraction of dietary
copper (average 2–5 mg/day) is absorbed by enterocytes in the duodenum and proximal …

The copper metabolism disorder Wilson's disease was first defined in 1912. Wilson's
disease can present with hepatic and neurological deficits, including dystonia and …

Wilson disease is one of the few movement disorders in which there are therapies that
modify disease progression. This disease is caused by copper overload primarily in the liver …

Wilson's disease (WD) is a rare autosomal recessive disorder of hepatocellular copper
deposition. The diagnostic approach to patients with WD may be challenging and is based …

Wilson's disease (WD) is characterised by a deleterious accumulation of copper in the liver
and brain. It is one of those rare genetic disorders that benefits from effective and lifelong …

Introduction: Schizophrenia spectrum disorders (SSD) represent a cluster of severe mental
illnesses. Diet has been identified as a modifiable risk factor and opportunity for intervention …

Copper is a required nutrient for life and particularly important to the brain and central
nervous system. Indeed, copper redox activity is essential to maintaining normal …

Abstract Wilson's disease (WD), which results from the defective ATP7B protein product, is
characterized by impaired copper metabolism and its clinical consequences vary from an …