The life span of anergic self-reactive B cells was determined by 5-bromo-2'-deoxyuridine
(BrdU) loading of tolerant double-transgenic (Dbl-Tg) mice produced by mating hen egg …

Deletion of autoreactive T cells during the induction of self tolerance has been directly
demonstrated. However, it is still relatively easy to detect self reactivity in normal healthy …

Transplantation tolerance is a state of immune unresponsiveness (or benign
responsiveness) to the presence of specific, nonself antigens in the absence of chronic …

The mechanisms involved in the initiation of anti-nuclear autoantibodies are unknown. In
this study, we show that one factor allowing anti-nuclear autoantibodies to develop is the …

The injection by the intravenous or intraperitoneal route of MHC class II incompatible spleen
cells into a normal, unirradiated mouse results in a chronic syndrome characterized by the …

The kinetics of potentially autoreactive B-cells were investigated in a double-transgenic
model of self-tolerance. Two types of transgenic mice were created for this purpose. In the …

Neuromuscular Junction Disorders Page 1 Page 2 Neuromuscular Junction Disorders
Diagnosis and Treatment Matthew N. Meriggioli Rush- Presbyterian-St. Luke’s Medical Center …

Sera from 69 healthy blood donors were screened for autoantibodies using Western blots of
human muscle fractions to assess whether prevalence and repertoires of autoantibodies …

Presentation of a soluble self antigen, the fifth component of complement (C5), is discussed
with emphasis on the differential ability of presentation by subpopulations of APC (dendritic …

Cytotoxic T‐lymphocyte precursors (CTL‐P) from control C57BL/6 mice and from mice of two
simian virus 40 (SV40) T‐antigen transgenic lines, 427 and 419, specifically nonresponsive …