Circadian disruption is pervasive and can occur at multiple organizational levels,
contributing to poor health outcomes at individual and population levels. Evidence points to …

A rate-limiting step in the prevention and early intervention of depressive disorders in young
people is our insufficient understanding of causal mechanisms. One plausible …

Aim Symptoms of bipolar disorder (BD) include changes in mood, activity, energy, sleep,
and appetite. Since many of these processes are regulated by circadian function, circadian …

A growing number of epidemiological and experimental studies has established that
circadian disruption is strongly associated with psychiatric disorders, including major …

Mood disorders account for a significant global disease burden, and pharmacological
innovation is needed as existing medications are suboptimal. A wide range of evidence …

Background Sleep and circadian disruption are associated with depression onset and
severity, but it is unclear which features (eg, sleep duration, chronotype) are important and …

Study objectives An evening circadian preference is common among adolescents. It is
characterized by a behavioral predilection for later sleep and wake timing and is associated …

Background Youth anxiety and depression have long been combined within the empirically
derived internalizing syndrome. The two conditions show substantial comorbidity, symptom …

Sleep, circadian rhythms, and mental health are reciprocally interlinked. Disruption to the
quality, continuity, and timing of sleep can precipitate or exacerbate psychiatric symptoms in …

Background Sleep and circadian rhythm problems intertwine with affective disorders.
Adolescents are particularly vulnerable to developing sleep and affective problems. Yet, the …