Placental pathology is necessary to understand common pregnancy complications and achieve an improved taxonomy of obstetrical disease

RW Redline, DJ Roberts, MM Parast, LM Ernst… - American journal of …, 2023 - Elsevier
The importance of a fully functioning placenta for a good pregnancy outcome is
unquestioned. Loss of function can lead to pregnancy complications and is often detected by …

SARS‐CoV2 and pregnancy: an invisible enemy?

S Verma, EB Carter… - American Journal of …, 2020 - Wiley Online Library
Coronavirus disease 2019 or COVID‐19 is an emerging viral disease caused by a member
of the betacoronavirus family, SARS‐CoV‐2. Since its' emergence in December 2019, it has …

Maternal Fc-mediated non-neutralizing antibody responses correlate with protection against congenital human cytomegalovirus infection

EC Semmes, IG Miller, CE Wimberly… - The Journal of …, 2022 - Am Soc Clin Investig
Human cytomegalovirus (HCMV) is the most common congenital infection and a leading
cause of stillbirth, neurodevelopmental impairment, and pediatric hearing loss worldwide …

Role of ACE2 in pregnancy and potential implications for COVID-19 susceptibility

N Azinheira Nobrega Cruz, D Stoll, DE Casarini… - Clinical …, 2021 - portlandpress.com
In times of coronavirus disease 2019 (COVID-19), the impact of severe acute respiratory
syndrome (SARS)-coronavirus (CoV)-2 infection on pregnancy is still unclear. The presence …

Transcriptomic profiling of human placenta in gestational diabetes mellitus at the single-cell level

Y Yang, F Guo, Y Peng, R Chen, W Zhou… - Frontiers in …, 2021 - frontiersin.org
Gestational diabetes mellitus (GDM) is associated with an increased risk of adverse
pregnancy outcomes. Increasing evidence shows that placentation defects may play …

Innate immune mechanisms to protect against infection at the human decidual-placental interface

R Hoo, A Nakimuli, R Vento-Tormo - Frontiers in immunology, 2020 - frontiersin.org
During pregnancy, the placenta forms the anatomical barrier between the mother and
developing fetus. Infectious agents can potentially breach the placental barrier resulting in …

Natural killer cells in the human uterine mucosa

V Male, A Moffett - Annual review of immunology, 2023 - annualreviews.org
The presence of granulated lymphocytes in the human uterine mucosa, known as decidua
during pregnancy, or endometrium otherwise, was first noted in the nineteenth century, but it …

Single-cell sequencing reveals novel cellular heterogeneity in uterine leiomyomas

J Goad, J Rudolph, M Zandigohar, M Tae… - Human …, 2022 - academic.oup.com
STUDY QUESTION What are the cellular composition and single-cell transcriptomic
differences between myometrium and leiomyomas as defined by single-cell RNA …

Human chorionic villous differentiation and placental development

J Kojima, M Ono, N Kuji, H Nishi - International Journal of Molecular …, 2022 - mdpi.com
In humans, the placenta provides the only fetomaternal connection and is essential for
establishing a pregnancy as well as fetal well-being. Additionally, it allows maternal …

Maternal and fetal T cells in term pregnancy and preterm labor

D Miller, M Gershater, R Slutsky, R Romero… - Cellular & Molecular …, 2020 - nature.com
Pregnancy is a state of immunological balance during which the mother and the developing
fetus must tolerate each other while maintaining sufficient immunocompetence to ward off …