[HTML][HTML] Malaria vaccines: facing unknowns

NMQ Palacpac, T Horii - F1000Research, 2020 - ncbi.nlm.nih.gov
Much of the gain in malaria control, in terms of regional achievements in restricting
geographical spread and reducing malaria cases and deaths, can be attributed to large …

[HTML][HTML] Comprehensive overview of vaccination during pregnancy in Europe

AA Simionescu, A Streinu-Cercel, FD Popescu… - Journal of Personalized …, 2021 - mdpi.com
Vaccinations during pregnancy can protect the mother from several infections, thus blocking
vertical transmission. Furthermore, through passive antibody transfer, the newborn can be …

A single full-length VAR2CSA ectodomain variant purifies broadly neutralizing antibodies against placental malaria isolates

JYA Doritchamou, JP Renn, B Jenkins, A Mahamar… - Elife, 2022 - elifesciences.org
Placental malaria (PM) is a deadly syndrome most frequent and severe in first pregnancies.
PM results from accumulation of Plasmodium falciparum-infected erythrocytes (IE) that …

[HTML][HTML] Re-orienting anti-malarial drug development to better serve pregnant women

M El Gaaloul, B Tornesi, F Lebus, D Reddy… - Malaria Journal, 2022 - Springer
Malaria is one of the most serious infectious diseases affecting predominantly low-and
middle-income countries, where pregnant women are among the populations at risk. There …

A review of combination adjuvants for malaria vaccines: a promising approach for vaccine development

S Pirahmadi, S Zakeri, ND Djadid, AA Mehrizi - International journal for …, 2021 - Elsevier
It is obvious that there is a critical need for an efficient malaria vaccine to accelerate malaria
eradication. Currently, recombinant subunit vaccination against malaria using proteins and …

[HTML][HTML] Unveiling the sugary secrets of Plasmodium parasites

F Goerdeler, PH Seeberger, O Moscovitz - Frontiers in microbiology, 2021 - frontiersin.org
Plasmodium parasites cause malaria disease, one of the leading global health burdens for
humanity, infecting hundreds of millions of people each year. Different glycans on the …

[HTML][HTML] Preclinical immunogenicity and safety of the cGMP-grade placental malaria vaccine PRIMVAC

A Chêne, S Gangnard, A Guadall, H Ginisty, O Leroy… - …, 2019 - thelancet.com
Background VAR2CSA is the lead antigen for developing a vaccine that would protect
pregnant women against placental malaria. A multi-system feasibility study has identified E …

Future vaccines in pregnancy

D Vress - Best Practice & Research Clinical Obstetrics & …, 2021 - Elsevier
Vaccination in pregnancy provides an important opportunity to target illnesses that are
known to impact pregnant women, fetal development, and newborns in particular. The ability …

[HTML][HTML] The molecular mechanism of cytoadherence to placental or tumor cells through VAR2CSA from Plasmodium falciparum

W Wang, Z Wang, X Yang, Y Gao, X Zhang, L Cao… - Cell discovery, 2021 - nature.com
Dear Editor, Pregnancy-associated malaria (PAM) threatened more than one million women
and their infants in endemic regions in 2019. This resulted in maternal anemia, stillbirth, and …

Multi-functional antibody profiling for malaria vaccine development and evaluation

DH Opi, L Kurtovic, JA Chan, JL Horton… - Expert Review of …, 2021 - Taylor & Francis
Introduction A vaccine would greatly accelerate current global efforts toward malaria
elimination. While a partially efficacious vaccine has been achieved for Plasmodium …