Malaria, a mosquito-borne infection, is the most widespread parasitic disease. Despite
numerous efforts to eradicate malaria, this disease is still a health concern worldwide. Owing …

PfRipr is a highly conserved asexual-blood stage malaria vaccine candidate against
Plasmodium falciparum. PfRipr5, a protein fragment of PfRipr inducing the most potent …

Immune effector responses against Plasmodium falciparum include antibody-mediated
activation of innate immune cells, which can induce Fc effector functions, including antibody …

In Sub-Saharan Africa, malaria continues to be associated with adverse pregnancy
outcomes including stillbirth, early neonatal death, preterm delivery, and low birth weight …

Introduction: Several malaria vaccines are under various phases of development with some
promising results. In placental malaria (PM) a deliberately anti-disease approach is …

Background: Plasmodium falciparum causes placental malaria, which results in adverse
outcomes for mother and child. P. falciparum-infected erythrocytes that express the parasite …

Malaria control has stalled in a number of African countries and novel approaches to malaria
control are needed for these areas. The encouraging results of a recent trial conducted in …

VAR2CSA, a multidomain Plasmodium falciparum protein, mediates the adherence of
parasite-infected red blood cells to chondroitin 4-sulfate (C4S) in the placenta, contributing …

Many pathogens evolve extensive genetic variation in virulence proteins as a strategy to
evade host immunity. This poses a significant challenge for the host to develop broadly …

During Plasmodium falciparum infection in pregnancy, VAR2CSA is expressed on the
surface of infected erythrocytes (IEs) and mediates their sequestration in the placenta. As a …