Major depressive disorder is one of the most disabling mental disorders worldwide.
Increasing preclinical and clinical studies have highlighted that compositional and functional …

Depression is a complex and biologically heterogeneous disorder. Recent studies have
shown that central nervous system (CNS) inflammation plays a key role in the development …

Scope The gut microbiota plays a prominent role in gut–brain interactions and gut dysbiosis
is involved in neuroinflammation. However, specific probiotics targeting neuroinflammation …

The NLRP3 inflammasome is an intracellular multiprotein complex that plays an essential
role in the innate immune system by identifying and eliminating a plethora of endogenous …

Increasing evidence suggests that activation of microglia‐induced neuroinflammation plays
a crucial role in the pathophysiology of depression. Consequently, targeting the central …

CD38 is involved in immune responses, cell proliferation, and has been identified in the
brain, where it is implicated in inflammation processes and psychiatric disorders. We …

Major depression disorder is a severe mental illness often linked with metabolic disorders.
Adiponectin is an adipocyte-secreted circulatory hormone with antidiabetic and glucose/lipid …

Inflammatory bowel disease (IBD) comprises Crohn's disease (CD) and ulcerative colitis
(UC) and is associated with neuropsychiatric symptoms like anxiety and depression. Both …

Activated microglia and subsequent release of pro-inflammatory cytokines result in
neuroinflammatory status which further damage neurological function including cognitive …

Incidence of anxiety and depression has been surging in recent years, causing unignorable
mental health crisis across the globe. Mounting studies demonstrated that overgrowth of …