Multiple nanotherapeutics have been approved for patients with cancer, but their effects on
survival have been modest and, in some examples, less than those of other approved …

Metastasis is a pivotal event that accelerates the prognosis of cancer patients towards
mortality. Therapies that aim to induce cell death in metastatic cells require a more detailed …

SHP2 mediates the activities of multiple receptor tyrosine kinase signaling and its function in
endothelial processes has been explored extensively. However, genetic studies on the role …

The strategy of synergetic chemodynamic treatment (CDT) and photothermal therapy (PTT)
to improve the anticancer effect has been a hot spot in the field of biomedicine. Herein, a …

Anoikis is a type of programmed cell death induced by loss of anchorage to the extracellular
matrix (ECM). Anoikis resistance (AR) is crucial for the survival of metastatic cancer cells in …

SLIT2 is a secreted polypeptide that guides migration of cells expressing Roundabout 1 and
2 (ROBO1 and ROBO2) receptors. Herein, we investigated SLIT2/ROBO signaling effects in …

Tumor vessel co-option is poorly understood, yet it is a resistance mechanism against anti-
angiogenic therapy (AAT). The heterogeneity of co-opted endothelial cells (ECs) and …

Worldwide, non-small cell lung cancer (NSCLC) has the highest morbidity and mortality of
all malignancies. The lack of responsiveness to checkpoint inhibitors is a central problem in …

Mast cells (MCs) are crucial cells participating in both innate and adaptive immune
processes that play important roles in protecting human health and in the pathophysiology of …

Macrophages sustain tumour progression by facilitating angiogenesis, promoting
immunosuppression, and enhancing cancer cell invasion and metastasis. They also …