Recent advances in the synthesis of pyrroles by multicomponent reactions

V Estévez, M Villacampa, JC Menéndez - Chemical Society Reviews, 2014 - pubs.rsc.org
Pyrrole is one of the most important one-ring heterocycles. The ready availability of suitably
substituted and functionalized pyrrole derivatives is essential for the progress of many …

Molecular diversity of spirooxindoles. Synthesis and biological activity

TL Pavlovska, RG Redkin, VV Lipson, DV Atamanuk - Molecular diversity, 2016 - Springer
Spirooxindoles are important synthetic targets possessing extended biological activity and
drug discovery applications. This review focuses on the various strategies for the …

Recent advances in new multicomponent synthesis of structurally diversified 1, 4-dihydropyridines

JP Wan, Y Liu - RSC advances, 2012 - pubs.rsc.org
1, 4-Dihydropyridines (DHPs) are one of the most important classes of heterocyclic
compounds as privileged pharmacophores. They are therefore attractive synthetic targets of …

Facile synthesis of dispirooxindole-fused heterocycles via domino 1, 4-dipolar addition and Diels–Alder reaction of in situ generated Huisgen 1, 4-dipoles

J Sun, Y Sun, H Gong, YJ Xie, CG Yan - Organic letters, 2012 - ACS Publications
A facile synthetic protocol was developed for the efficient synthesis of complex
dispirooxindole-fused heterocycles via a three-component reaction. The key strategies …

Efficient construction of diverse spiro [indoline-3, 4′-pyrrolo [3, 4-b] pyridines] via [3+ 3] cycloaddition of MBH carbonates of isatins with β-enamino maleimides

LN Pan, J Sun, XY Liu, CG Yan - Organic & Biomolecular Chemistry, 2022 - pubs.rsc.org
An efficient method to construct unique spiro [indoline-3, 4′-pyrrolo [3, 4-b] pyridines] was
successfully developed via a DABCO promoted formal [3+ 3] cycloaddition reaction of MBH …

Highly efficient synthesis of polysubstituted pyrroles via four-component domino reaction

X Feng, Q Wang, W Lin, GL Dou, ZB Huang… - Organic letters, 2013 - ACS Publications
A highly efficient, catalyst-free synthesis of polysubstituted pyrroles by means of a novel four-
component domino reaction of an arylglyoxal monohydrate, an aniline, a dialkyl but-2 …

Review of synthesis of spiro heterocyclic compounds from isatin

MA Borad, MN Bhoi, NP Prajapati… - Synthetic …, 2014 - Taylor & Francis
Isatin is an essential building block in organic synthesis and shows various biological
activities. The most attractive application of isatin in organic synthesis is undoubtedly in the …

Enamines and their variants as intermediates for synthesis of aza-heterocycles with applications in MCRs

D Magoo, K Aggarwal, S Gupta, K Meena - Tetrahedron, 2022 - Elsevier
This review brings together the versatility of enamine intermediates and multicomponent
reactions that have been coalesced to generate a diverse library of nitrogen containing …

Cu (OTf) 2 catalyzed three component reaction: Efficient synthesis of spiro [indoline-3, 4′-pyrano [3, 2-b] pyran derivatives and their anticancer potency towards A549 …

K Parthasarathy, C Praveen, C Balachandran… - Bioorganic & medicinal …, 2013 - Elsevier
Cu (OTf) 2 catalyzed efficient synthesis of spiropyrano [3, 2-b] pyran-4 (8H)-ones is
accomplished via one-pot three component reaction between isatin, kojic acid and active …

A facile and efficient procedure for one-pot four-component synthesis of polysubstituted spiro pyrano [2, 3-c] pyrazole and spiro 1, 4-dihydropyridine catalyzed by a …

T Liu, YH Lai, YQ Yu, DZ Xu - New Journal of Chemistry, 2018 - pubs.rsc.org
A simple and efficient synthetic protocol for the syntheses of spiro pyrano [2, 3-c] pyrazole
and spiro 1, 4-dihydropyridine derivatives via a one pot four-component reaction catalyzed …