Deciphering cell–cell interactions and communication from gene expression
E Armingol, A Officer, O Harismendy… - Nature Reviews …, 2021 - nature.com
Cell–cell interactions orchestrate organismal development, homeostasis and single-cell
functions. When cells do not properly interact or improperly decode molecular messages …
functions. When cells do not properly interact or improperly decode molecular messages …
Decoding post-translational modification crosstalk with proteomics
Post-translational modification (PTM) of proteins allows cells to regulate protein functions,
transduce signals and respond to perturbations. PTMs expand protein functionality and …
transduce signals and respond to perturbations. PTMs expand protein functionality and …
The functional landscape of the human phosphoproteome
Protein phosphorylation is a key post-translational modification regulating protein function in
almost all cellular processes. Although tens of thousands of phosphorylation sites have …
almost all cellular processes. Although tens of thousands of phosphorylation sites have …
[HTML][HTML] Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling
Regulatory protein phosphorylation controls normal and pathophysiological signaling in
eukaryotic cells. Despite great advances in mass-spectrometry-based proteomics, the …
eukaryotic cells. Despite great advances in mass-spectrometry-based proteomics, the …
Effects of α-tubulin acetylation on microtubule structure and stability
L Eshun-Wilson, R Zhang, D Portran… - Proceedings of the …, 2019 - National Acad Sciences
Acetylation of K40 in α-tubulin is the sole posttranslational modification to mark the luminal
surface of microtubules. It is still controversial whether its relationship with microtubule …
surface of microtubules. It is still controversial whether its relationship with microtubule …
Challenges and emergent solutions for LC‐MS/MS based untargeted metabolomics in diseases
In the past decade, advances in liquid chromatography‐mass spectrometry (LC‐MS) have
revolutionized untargeted metabolomics analyses. By mining metabolomes more deeply …
revolutionized untargeted metabolomics analyses. By mining metabolomes more deeply …
SUMO and the robustness of cancer
JS Seeler, A Dejean - Nature Reviews Cancer, 2017 - nature.com
Post-translational protein modification by small ubiquitin-like modifier (SUMO), termed
sumoylation, is an important mechanism in cellular responses to stress and one that …
sumoylation, is an important mechanism in cellular responses to stress and one that …
CRISPR-mediated tagging of endogenous proteins with a luminescent peptide
MK Schwinn, T Machleidt, K Zimmerman… - ACS chemical …, 2018 - ACS Publications
Intracellular signaling pathways are mediated by changes in protein abundance and post-
translational modifications. A common approach for investigating signaling mechanisms and …
translational modifications. A common approach for investigating signaling mechanisms and …
The roles of post-translational modifications in the context of protein interaction networks
Among other effects, post-translational modifications (PTMs) have been shown to exert their
function via the modulation of protein-protein interactions. For twelve different main PTM …
function via the modulation of protein-protein interactions. For twelve different main PTM …
[HTML][HTML] Pan-cancer analysis of post-translational modifications reveals shared patterns of protein regulation
Post-translational modifications (PTMs) play key roles in regulating cell signaling and
physiology in both normal and cancer cells. Advances in mass spectrometry enable high …
physiology in both normal and cancer cells. Advances in mass spectrometry enable high …