Overview of the pharmacokinetics and pharmacodynamics of URAT1 inhibitors for the treatment of hyperuricemia and gout
Z Hou, A Ma, J Mao, D Song, X Zhao - Expert Opinion on Drug …, 2023 - Taylor & Francis
Introduction Hyperuricemia is a common metabolic disease, which is a risk factor for gouty
arthritis and ureteral stones and may also lead to cardiovascular and chronic kidney disease …
arthritis and ureteral stones and may also lead to cardiovascular and chronic kidney disease …
[HTML][HTML] Acute oral toxicity assessment and anti-hyperuricemic activity of Alocasia longiloba extracts on Sprague-Dawley rats
Hyperuricemia is defined as a metabolic abnormality that occurs when serum uric acid (UA)
level is abnormally high in the body. We previously reported that A. longiloba possesses …
level is abnormally high in the body. We previously reported that A. longiloba possesses …
Systematic review and model-based analysis to identify whether renal safety risks of URAT1 inhibitors are fully determined by uric acid-lowering efficacies
Y Qu, Y Yu, J Pan, H Li, C Cui, D Liu - Seminars in Arthritis and Rheumatism, 2023 - Elsevier
Objective: Renal safety risk is currently an important factor that hinders the development of
uric acid transporter 1 (URAT1) inhibitors. This study aimed to compare the renal safety and …
uric acid transporter 1 (URAT1) inhibitors. This study aimed to compare the renal safety and …
[HTML][HTML] Elevated serum uric acid is associated with poor survival in advanced HCC patients and febuxostat improves prognosis in HCC rats
L Wu, W Yang, Y Zhang, X Du, N Jin, W Chen… - Frontiers in …, 2021 - frontiersin.org
Objective: Serum uric acid is associated with tumor progression and hepatocarcinogenesis.
Here, we aimed to determine whether serum uric acid is related to the survival time of …
Here, we aimed to determine whether serum uric acid is related to the survival time of …
Verinurad does not prolong QTc interval: a thorough QT study using concentration–QTc modelling
J Parkinson, C Dota, C Källgren… - British Journal of …, 2023 - Wiley Online Library
Aim This thorough QT/QTc (TQT) study was conducted to evaluate the risk of QT
prolongation for verinurad when combined with allopurinol. Verinurad is a novel, urate anion …
prolongation for verinurad when combined with allopurinol. Verinurad is a novel, urate anion …
[图书][B] Choroby XXI wieku: diagnostyka, prewencja i leczenie
A Danielewska, I Mołdoch-Mendoń, WN Tygiel - 2022 - researchgate.net
Dyslipidemia jest zaburzeniem metabolizmu, które stanowi jedną z najczęściej
rozpoznawanych i leczonych chorób przewlekłych. Pojęcie to odnosi się do …
rozpoznawanych i leczonych chorób przewlekłych. Pojęcie to odnosi się do …
[图书][B] Mixed Effects Modeling of Deterministic and Stochastic Dynamical Systems-Methods and Applications in Drug Development
J Leander - 2021 - search.proquest.com
Mathematical models based on ordinary differential equations (ODEs) are commonly used
for describing the evolution of a system over time. In drug development, pharmacokinetic …
for describing the evolution of a system over time. In drug development, pharmacokinetic …
[PDF][PDF] Assessment of Relation of Serum Uric Acid & Micro Albuminuria in the Patients of Diabetes Mellitus Type-2 for Early Detection of Diabetic Nephropathy
M Shah, A Aziz, S Ashraf, S Husain, R Bano, SN Fatima… - researchgate.net
ABSTRACT Background: Diabetic Nephropathy is one of the serious and life perilous
complications of diabetes mellitus. Prolong duration of diabetes, no proper care and …
complications of diabetes mellitus. Prolong duration of diabetes, no proper care and …