Inflammation contributes centrally to cardiovascular diseases, and anti-inflammatory
treatments can reduce cardiovascular events. The JAK–STAT pathway is an emerging target …

Transportation noise is a ubiquitous urban exposure. In 2018, the World Health Organization
concluded that chronic exposure to road traffic noise is a risk factor for ischemic heart …

Background—Angiotensin-converting enzyme 2 (ACE2) is a pleiotropic
monocarboxypeptidase capable of metabolizing several peptide substrates. We …

Abstract Angiotensin II (Ang II) activates a wide spectrum of signaling responses via the AT1
receptor (AT1R) that mediate its physiological control of blood pressure, thirst, and sodium …

Proteins of the interleukin-6 (IL-6) family bind to receptors in the plasma membrane.
Subsequent signal transduction involves activation of the janus kinase (JAK) and signal …

Circulating levels of interleukin (IL)–6 and related cytokines are elevated in patients with
congestive heart failure and after myocardial infarction. Serum IL-6 concentrations are …

Expression of the STAT3 transcription factor in the heart is cardioprotective and decreases
the levels of reactive oxygen species. Recent studies indicate that a pool of STAT3 resides …

Ang II, the primary effector pleiotropic hormone of the renin–angiotensin system (RAS)
cascade, mediates physiological control of blood pressure and electrolyte balance through …

We examined the role for the JAK/STAT signaling pathway in acute opioid-induced
cardioprotection (OIC) and whether opioid-induced glycogen synthase kinase-3β (GSK-3β) …

The molecular mechanisms through which ghrelin exerts its cardioprotective effects during
cardiac remodeling post-myocardial infarction (MI) are poorly understood. The aim of this …