Butyrylcholinesterase (BChE) is present in plasma and numerous cells and organs. Its
physiological function (s) is (are) still unclear. However, this enzyme is of pharmacological …

Cocaine is a widely abused, hepatotoxic drug without an FDA-approved pharmacotherapy
specific for cocaine addiction or overdose. It is recognized as a promising therapeutic …

As well known, cocaine induces stimulant effects and dopamine transporter (DAT) trafficking
to the plasma membrane of dopaminergic neurons. In the present study, we examined …

A combined computational and experimental study has been carried out to explore and test
a quantitative correlation relationship between the relative catalytic efficiency (RCE) of …

It is recognized as a promising therapeutic strategy for cocaine use disorder to develop an
efficient enzyme which can rapidly convert cocaine to physiologically inactive metabolites …

Cocaine dependence is a serious world-wide public health problem without an FDA-
approved pharmacotherapy. We recently designed and discovered a highly efficient long …

Introduction We have previously described the preclinical developments in enzyme-loaded
red blood cells to be used in the treatment of several rare diseases, as well as in chronic …

As most cocaine users drink alcohol, it is interesting to understand how a non-lethal dose of
alcohol affects the metabolism and toxicity of cocaine. In this study, we examined the …

Introduction Metabolomics produces vast quantities of data but determining which
metabolites are the most relevant to the disease or disorder of interest can be challenging …

Актуальность. Хирургическое лечение повреждений лодыжечного сегмента
осуществляется в соответствии с принципами лечения внутрисуставных переломов …