An Updated View of the Trypanosoma cruzi Life Cycle: Intervention Points for an Effective Treatment
J Martín-Escolano, C Marín, MJ Rosales… - ACS Infectious …, 2022 - ACS Publications
Chagas disease (CD) is a parasitic, systemic, chronic, and often fatal illness caused by
infection with the protozoan Trypanosoma cruzi. The World Health Organization classifies …
infection with the protozoan Trypanosoma cruzi. The World Health Organization classifies …
Innovation in neglected tropical disease drug discovery and development
HB Weng, HX Chen, MW Wang - Infectious diseases of poverty, 2018 - mednexus.org
Background: Neglected tropical diseases (NTDs) are closely related to poverty and affect
over a billion people in developing countries. The unmet treatment needs cause high …
over a billion people in developing countries. The unmet treatment needs cause high …
[HTML][HTML] Drug discovery for chagas disease: A viewpoint
JM Kratz - Acta tropica, 2019 - Elsevier
Chagas disease is a neglected tropical disease caused by the protozoan parasite
Trypanosoma cruzi. It is a significant public health problem, affecting millions of people …
Trypanosoma cruzi. It is a significant public health problem, affecting millions of people …
Current advances in drug discovery for Chagas disease
CB Scarim, DH Jornada, RC Chelucci… - European journal of …, 2018 - Elsevier
Chagas disease, also known as American trypanosomiasis, is one of the 17 neglected
tropical diseases (NTDs) according to World Health Organization. It is estimated that 8–10 …
tropical diseases (NTDs) according to World Health Organization. It is estimated that 8–10 …
Advances in preclinical approaches to Chagas disease drug discovery
F Villalta, G Rachakonda - Expert opinion on drug discovery, 2019 - Taylor & Francis
ABSTRACT Introduction: Chagas disease affects 8–10 million people worldwide, mainly in
Latin America. The current therapy for Chagas disease is limited to nifurtimox and …
Latin America. The current therapy for Chagas disease is limited to nifurtimox and …
Chagas disease: perspectives on the past and present and challenges in drug discovery
Chagas disease still has no effective treatment option for all of its phases despite being
discovered more than 100 years ago. The development of commercial drugs has been …
discovered more than 100 years ago. The development of commercial drugs has been …
Review of pharmacological options for the treatment of Chagas disease
F Lascano, F García Bournissen… - British journal of clinical …, 2022 - Wiley Online Library
Chagas disease (CD) is a worldwide problem, with over 8 million people infected in both
rural and urban areas. CD was first described over a century ago, but only two drugs are …
rural and urban areas. CD was first described over a century ago, but only two drugs are …
Multifunctional organometallic compounds for the treatment of Chagas disease: Re (i) tricarbonyl compounds with two different bioactive ligands
Chagas' disease (American Trypanosomiasis) is an ancient and endemic illness in Latin
America caused by the protozoan parasite Trypanosoma cruzi. Although there is an urgent …
America caused by the protozoan parasite Trypanosoma cruzi. Although there is an urgent …
State-of-the-art in the drug discovery pathway for Chagas disease: A framework for drug development and target validation
JC Gabaldón-Figueira… - … and Reports in …, 2023 - Taylor & Francis
Chagas disease is the most important protozoan infection in the Americas, and constitutes a
significant public health concern throughout the world. Development of new medications …
significant public health concern throughout the world. Development of new medications …
Why hasn't there been more progress in new Chagas disease drug discovery?
AB Vermelho, GC Rodrigues… - Expert Opinion on Drug …, 2020 - Taylor & Francis
Introduction: Chagas disease (CD) is a neglected disease caused by the protozoan parasite
Trypanosoma cruzi. In terms of novel drug discovery, there has been no progress since the …
Trypanosoma cruzi. In terms of novel drug discovery, there has been no progress since the …