An Updated View of the Trypanosoma cruzi Life Cycle: Intervention Points for an Effective Treatment

J Martín-Escolano, C Marín, MJ Rosales… - ACS Infectious …, 2022 - ACS Publications
Chagas disease (CD) is a parasitic, systemic, chronic, and often fatal illness caused by
infection with the protozoan Trypanosoma cruzi. The World Health Organization classifies …

Innovation in neglected tropical disease drug discovery and development

HB Weng, HX Chen, MW Wang - Infectious diseases of poverty, 2018 - mednexus.org
Background: Neglected tropical diseases (NTDs) are closely related to poverty and affect
over a billion people in developing countries. The unmet treatment needs cause high …

[HTML][HTML] Drug discovery for chagas disease: A viewpoint

JM Kratz - Acta tropica, 2019 - Elsevier
Chagas disease is a neglected tropical disease caused by the protozoan parasite
Trypanosoma cruzi. It is a significant public health problem, affecting millions of people …

Current advances in drug discovery for Chagas disease

CB Scarim, DH Jornada, RC Chelucci… - European journal of …, 2018 - Elsevier
Chagas disease, also known as American trypanosomiasis, is one of the 17 neglected
tropical diseases (NTDs) according to World Health Organization. It is estimated that 8–10 …

Advances in preclinical approaches to Chagas disease drug discovery

F Villalta, G Rachakonda - Expert opinion on drug discovery, 2019 - Taylor & Francis
ABSTRACT Introduction: Chagas disease affects 8–10 million people worldwide, mainly in
Latin America. The current therapy for Chagas disease is limited to nifurtimox and …

Chagas disease: perspectives on the past and present and challenges in drug discovery

FRP Mansoldo, F Carta, A Angeli, VS Cardoso… - Molecules, 2020 - mdpi.com
Chagas disease still has no effective treatment option for all of its phases despite being
discovered more than 100 years ago. The development of commercial drugs has been …

Review of pharmacological options for the treatment of Chagas disease

F Lascano, F García Bournissen… - British journal of clinical …, 2022 - Wiley Online Library
Chagas disease (CD) is a worldwide problem, with over 8 million people infected in both
rural and urban areas. CD was first described over a century ago, but only two drugs are …

Multifunctional organometallic compounds for the treatment of Chagas disease: Re (i) tricarbonyl compounds with two different bioactive ligands

M Soba, G Scalese, F Casuriaga, N Pérez… - Dalton …, 2023 - pubs.rsc.org
Chagas' disease (American Trypanosomiasis) is an ancient and endemic illness in Latin
America caused by the protozoan parasite Trypanosoma cruzi. Although there is an urgent …

State-of-the-art in the drug discovery pathway for Chagas disease: A framework for drug development and target validation

JC Gabaldón-Figueira… - … and Reports in …, 2023 - Taylor & Francis
Chagas disease is the most important protozoan infection in the Americas, and constitutes a
significant public health concern throughout the world. Development of new medications …

Why hasn't there been more progress in new Chagas disease drug discovery?

AB Vermelho, GC Rodrigues… - Expert Opinion on Drug …, 2020 - Taylor & Francis
Introduction: Chagas disease (CD) is a neglected disease caused by the protozoan parasite
Trypanosoma cruzi. In terms of novel drug discovery, there has been no progress since the …