Pharmacokinetic changes during pregnancy and their clinical relevance

R Loebstein, A Lalkin, G Koren - Clinical pharmacokinetics, 1997 - Springer
The dynamic physiological changes that occur in the maternal-placental-fetal unit during
pregnancy influence the pharmacokinetic processes of drug absorption, distribution and …

Drug therapy for breast-feeding women

S Ito - New England Journal of Medicine, 2000 - Mass Medical Soc
Breast-feeding is the best method of feeding neonates and young infants. 1 Its popularity
has increased in recent years, 2 although in 1995 only about 60 percent of new mothers in …

Modeling drug passage into human milk

PO Anderson, JB Sauberan - Clinical Pharmacology & …, 2016 - Wiley Online Library
Breastfeeding has positive health consequences for both the breastfed infant and the
nursing mother. 1, 2 Although information on drug use during lactation is available through …

Drug excretion into breast milk—overview

S Ito, A Lee - Advanced drug delivery reviews, 2003 - Elsevier
Breastfeeding is the optimal form of infant feeding for the first months of an infant's life, and
the majority of healthy women initiate breastfeeding after the birth of their infant. However …

Excretion of antihypertensive medication into human breast milk: a systematic review

KS Beardmore, JM Morris… - Hypertension in …, 2002 - Taylor & Francis
Objective: To establish which antihypertensive medications are safe for use while
breastfeeding, by reviewing the available evidence. Methods: Reports of studies examining …

Opioids in breast milk: pharmacokinetic principles and clinical implications

S Ito - The Journal of Clinical Pharmacology, 2018 - Wiley Online Library
Safety of maternal drug therapy during breastfeeding may be assessed from estimated
levels of drug exposure of the infant through milk. Pharmacokinetic (PK) principles predict …

Pre-exposure prophylaxis use by breastfeeding HIV-uninfected women: a prospective short-term study of antiretroviral excretion in breast milk and infant absorption

KK Mugwanya, CW Hendrix, NR Mugo… - PLoS …, 2016 - journals.plos.org
Background As pre-exposure prophylaxis (PrEP) becomes more widely used in
heterosexual populations, an important consideration is its safety in infants who are …

Antidepressant use during pregnancy: the benefit-risk ratio

G Koren, H Nordeng - American journal of obstetrics and gynecology, 2012 - Elsevier
Antidepressants are used commonly in pregnancy. Physicians who provide health care for
pregnant women with depression must balance maternal well-being with potential fetal risks …

Infant drug exposure via breast milk

RHJ Verstegen, PO Anderson… - British Journal of Clinical …, 2022 - Wiley Online Library
More than half of women take medications during breastfeeding, predisposing their infants
to medication exposure via breast milk. As a result, adverse drug reactions may emerge in …

Anticonvulsants and breast feeding: a critical review

B Bar-Oz, I Nulman, G Koren, S Ito - Pediatric Drugs, 2000 - Springer
Progress in the diagnosis and management of seizure disorders and the availability of
effective anticonvulsive medications has enabled increasing numbers of epileptic women of …