Obesity is reaching epidemic proportions and imposes major negative health crises and an
economic burden in both high and low income countries. The multifaceted nature of obesity …

Maternal metabolic adaptations during pregnancy ensure appropriate nutrient supply to the
developing fetus. This is facilitated by reductions in maternal peripheral insulin sensitivity …

Aim The current study investigated the impact of maternal obesity on placental phenotype in
relation to fetal growth and sex. Methods Female C57BL6/J mice were fed either a diet high …

In vivo and in vitro studies demonstrate that mitochondria in the oocyte, are susceptible to
damage by suboptimal pre/pregnancy conditions, such as obesity. These suboptimal …

Exposures to adverse conditions in utero can lead to permanent changes in the structure
and function of key physiological systems in the developing fetus, increasing the risk of …

The placental exposome represents the sum of all placental exposures, and through its
influence on placental function can affect an individual's susceptibility to cardio-metabolic …

Conditions such as small for gestational age (SGA), which is defined as birthweight less
than 10th percentile for gestational age can predispose to neurodevelopmental …

Male and female offspring of obese mothers are known to differ extensively in their
metabolic adaptation and later development of complications. We investigate the sex …

The embryo produced by in vitro oocyte maturation, fertilization, and embryonic
development is an important resource for genetic improvement and has the potential to …

Maternal obesity is associated with an increased risk of hepatic metabolic dysfunction for
both mother and offspring and targeted interventions to address this growing metabolic …