Environmental and genetic factors involved in plant protection-associated secondary metabolite biosynthesis pathways

X Zhan, Z Chen, R Chen, C Shen - Frontiers in Plant Science, 2022 - frontiersin.org
Plant specialized metabolites (PSMs) play essential roles in the adaptation to harsh
environments and function in plant defense responses. PSMs act as key components of …

Natural bioactive products as promising therapeutics: A review of natural product-based drug development

CB Aware, DN Patil, SS Suryawanshi, PR Mali… - South African Journal of …, 2022 - Elsevier
Since ancient times, natural medicines have had paramount importance in bolstering
biotherapeutics to treat various diseases. The World Health Organization (WHO) revealed …

The methyl jasmonate-responsive transcription factor SmMYB1 promotes phenolic acid biosynthesis in Salvia miltiorrhiza

W Zhou, M Shi, C Deng, S Lu, F Huang… - Horticulture …, 2021 - academic.oup.com
Water-soluble phenolic acids are major bioactive compounds in the medicinal plant species
Salvia miltiorrhiza. Phenolic acid biosynthesis is induced by methyl jasmonate (MeJA) in this …

Effects of various Agrobacterium rhizogenes strains on hairy root induction and analyses of primary and secondary metabolites in Ocimum basilicum

R Sathasivam, M Choi, R Radhakrishnan… - Frontiers in Plant …, 2022 - frontiersin.org
The hairy root (HR) culture system is an excellent alternative strategy to the whole plant
system for producing valuable compounds. However, selection of suitable Agrobacterium …

A novel WRKY34-bZIP3 module regulates phenolic acid and tanshinone biosynthesis in Salvia miltiorrhiza

M Shi, R Zhu, Y Zhang, S Zhang, T Liu, K Li, S Liu… - Metabolic …, 2022 - Elsevier
Phenolic acids and tanshinones are main bioactive compounds produced in Salvia
miltiorrhiza widely used in treatment of cardiovascular diseases, which could be promoted …

Genetic manipulation and bioreactor culture of plants as a tool for industry and its applications

T Kowalczyk, A Merecz-Sadowska, L Picot… - Molecules, 2022 - mdpi.com
In recent years, there has been a considerable increase in interest in the use of transgenic
plants as sources of valuable secondary metabolites or recombinant proteins. This has been …

Research progress on the biosynthesis and metabolic engineering of the anti-cancer drug camptothecin in Camptotheca acuminate

X Fan, X Lin, Q Ruan, J Wang, Y Yang, M Sheng… - Industrial Crops and …, 2022 - Elsevier
Abstract Camptothecin (CPT), a well-known natural anti-cancer drug, is produced from
woody plant Camptotheca acuminata. Up to now, two CPT-derivatives, irinotecan and …

Strategies to modulate specialized metabolism in Mediterranean crops: From molecular aspects to field

R Balestrini, C Brunetti, M Cammareri… - International Journal of …, 2021 - mdpi.com
Plant specialized metabolites (SMs) play an important role in the interaction with the
environment and are part of the plant defense response. These natural products are volatile …

Endophytic fungus Cladosporium tenuissimum DF11, an efficient inducer of tanshinone biosynthesis in Salvia miltiorrhiza roots

H Chen, J Chen, Y Qi, S Chu, Y Ma, L Xu, S Lv… - Phytochemistry, 2022 - Elsevier
Salvia miltiorrhiza is a traditional medicinal plant mainly used for cardiovascular and
cerebrovascular disease treatment. Tanshinones are the main bioactive constituents of S …

JA-Responsive Transcription Factor SmMYB97 Promotes Phenolic Acid and Tanshinone Accumulation in Salvia miltiorrhiza

L Li, D Wang, L Zhou, X Yu, X Yan… - Journal of Agricultural …, 2020 - ACS Publications
Phenolic acids and tanshinones are active principles in Salvia miltiorrhiza Bunge
administered for cardiovascular and cerebrovascular diseases. Jasmonic acid (JA) …