Ferroptosis is a newly discovered type of cell death that differs from traditional apoptosis and
necrosis and results from iron‐dependent lipid peroxide accumulation. Ferroptotic cell death …

Sorafenib is the treatment of reference for advanced hepatocellular carcinoma (HCC), the
most frequent form of primary liver tumour. The loss of function of the retinoblastoma (Rb) …

Sorafenib, an orally-available kinase inhibitor, is the only medical treatment with a proven
efficacy against Hepatocellular Carcinoma (HCC). Although the overall clinical efficacy of …

Background Sorafenib, a kinase inhibitor active against various solid tumours, induces
oxidative stress and ferroptosis, a new form of oxidative necrosis, in some cancer cells …

Sorafenib is the only approved systemic treatment for advanced hepatocellular carcinoma
patients and all the recently published randomized controlled trials on new systemic drugs …

The tumor inhibitory potential of the highly active chemerin-156 isoform was described in
orthotopic models of hepatocellular carcinoma (HCC). The majority of HCC arises in the …

Abstract The RAS-RAF-MEK-ERK cascade is a key oncogenic signal transduction pathway
activated in many types of tumours in humans. Sorafenib, the medical treatment of reference …

Background Despite recent progress, investigating the impact of targeted therapies on Head
and Neck Squamous Cell Carcinoma (HNSCC) remains a challenge. We investigated …

Sorafenib (SFB), a multi‐kinase inhibitor, is the only approved drug for treating
hepatocellular carcinoma (HCC). However, SFB shows low efficacy in many cases. HCC …

Background Cetuximab is a targeted therapy with demonstrated efficacy in the management
of head and neck squamous cell carcinoma (HNSCC). However, no laboratory assay is …