Myasthenia gravis (MG) is an autoimmune disorder that affects the neuromuscular junction,
leading to muscle weakness and fatigue. MG is caused by antibodies against the …

Introduction Inappropriate antibiotic use contributes to antimicrobial resistance. High-income
countries have high rates of antibiotic use, with a prevalence of health inequalities amongst …

Kidney transplanted patients are a unique population with intrinsic susceptibility to viral and
bacterial infections, mainly (but not exclusively) due to continuous immunosuppression. In …

Abstract Clonal complex 4821 (CC4821) Neisseria meningitidis, usually resistant to
quinolones but susceptible to penicillin and third-generation cephalosporins, is increasing …

Background Penicillin and ciprofloxacin are important for invasive meningococcal disease
(IMD) management and prevention. IMD cases caused by penicillin-and ciprofloxacin …

ABSTRACT Introduction Following the CHAMPION-NMOSD trial, the FDA recently granted
approval for ravulizumab, a humanized monoclonal antibody against complement C5 …

Paroxysmal nocturnal hemoglobinuria (PNH) is a clonal stem cell disease characterized by
intravascular hemolysis due to the targeting of affected red blood cells by the complement …

The complement system is a tightly controlled signaling network that plays a role in innate
immune surveillance. However, abnormal signaling through this pathway contributes to …

Background/Objectives: Eculizumab is a first-line treatment for atypical hemolytic uremic
syndrome (aHUS), and patients undergoing eculizumab therapy may become more …

Complement-mediated kidney diseases are ultrarare conditions characterized by excess
complement activation related in most cases to complement gene variants or circulating …