Membrane-bound P2-receptors mediate the actions of extracellular nucleotides in cell-to-
cell signalling. P2X-receptors are ligand-gated ion channels, whereas P2Y-receptors belong …

Membrane-bound P2-receptors mediate the actions of extracellular nucleotides in cell-to-
cell signalling. P2X-receptors are ligand-gated ion channels, whereas P2Y-receptors belong …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

ATP functions as a fast neurotransmitter through the specific activation of a family of ligand-
gated ion channels termed P2X receptors. In this report, six distinct recombinant P2X …

Uridine 5′-diphosphoglucose (UDP-glucose) has a well established biochemical role as a
glycosyl donor in the enzymatic biosynthesis of carbohydrates. It is less well known that UDP …

Clones encoding a new human P2Y receptor, provisionally called P2Y 11, have been
isolated from human placenta complementary DNA and genomic DNA libraries. The 1113 …

Abstract P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular
nucleotides. There are eight mammalian P2Y receptor subtypes divided into two subgroups …

Adenosine diphosphate (ADP), an important platelet agonist, acts through 2 G-protein-
coupled receptors (GPCRs), P2Y1 and P2Y12, which signal through Gq and Gi …

To test for the role of the P2Y 2 receptor (P2Y 2-R) in the regulation of nucleotide-promoted
Ca 2+ signaling in the lung, we generated P2Y 2-R-deficient (P2Y 2-R (−/−)) mice and …

Platelet activation plays an essential role in thrombosis. ADP-induced platelet aggregation is
mediated by two distinct G protein-coupled ADP receptors, Gq-linked P2Y1, and Gi-linked …