Role of NSD1 as potential therapeutic target in tumor
C Yang, K Wang, Q Liang, TT Tian, Z Zhong - Pharmacological Research, 2021 - Elsevier
Nuclear receptor binding SET Domain Protein 1 (NSD1) is a bifunctional transcriptional
regulatory protein that encodes histone methyltransferase. Mono-and di-methylation of …
regulatory protein that encodes histone methyltransferase. Mono-and di-methylation of …
[HTML][HTML] Single cell transcriptomic analysis of HPV16-infected epithelium identifies a keratinocyte subpopulation implicated in cancer
MC Bedard, T Chihanga, A Carlile, R Jackson… - Nature …, 2023 - nature.com
Persistent HPV16 infection is a major cause of the global cancer burden. The viral life cycle
is dependent on the differentiation program of stratified squamous epithelium, but the …
is dependent on the differentiation program of stratified squamous epithelium, but the …
[HTML][HTML] ACE2 and TMPRSS2 expression by clinical, HLA, immune, and microbial correlates across 34 human cancers and matched normal tissues: implications for …
Background Pandemic COVID-19 by severe acute respiratory syndrome (SARS)
coronavirus 2 (SARS-CoV-2) infection is facilitated by the ACE2 receptor and protease …
coronavirus 2 (SARS-CoV-2) infection is facilitated by the ACE2 receptor and protease …
[HTML][HTML] Mutation signature analysis identifies increased mutation caused by tobacco smoke associated DNA adducts in larynx squamous cell carcinoma compared …
AP South, NY den Breems, T Richa, U Nwagu… - Scientific reports, 2019 - nature.com
Squamous cell carcinomas of the head and neck (HNSCC) arise from mucosal keratinocytes
of the upper aero-digestive tract. Despite a common cell of origin and similar driver-gene …
of the upper aero-digestive tract. Despite a common cell of origin and similar driver-gene …
[HTML][HTML] Immune-based classification of HPV-associated oropharyngeal cancer with implications for biomarker-driven treatment de-intensification
Background There is significant interest in treatment de-escalation for human papillomavirus-
associated (HPV+) oropharyngeal squamous cell carcinoma (OPSCC) patients given the …
associated (HPV+) oropharyngeal squamous cell carcinoma (OPSCC) patients given the …
All HPV-negative head and neck cancers are not the same: Analysis of the TCGA dataset reveals that anatomical sites have distinct mutation, transcriptome, hypoxia …
Purpose Head and neck squamous cell carcinoma (HNSCC) affects various anatomical
sites, which often dictates whether the cancer is managed with primary surgery or radiation …
sites, which often dictates whether the cancer is managed with primary surgery or radiation …
[HTML][HTML] Differential gene expression analysis of HNSCC tumors deciphered tobacco dependent and independent molecular signatures
Head and neck cancer is the sixth most common cancer worldwide, with tobacco as the
leading cause. However, it is increasing in non-tobacco users also, hence limiting our …
leading cause. However, it is increasing in non-tobacco users also, hence limiting our …
Sex disparities in head & neck cancer driver genes: An analysis of the TCGA dataset
Objectives Survival in head and neck squamous cell carcinoma (HNSCC) has been
associated with patient sex, typically with males experiencing poorer outcomes. It is unclear …
associated with patient sex, typically with males experiencing poorer outcomes. It is unclear …
[HTML][HTML] Lysine methyltransferase NSD1 and cancers: any role in melanoma?
Simple Summary Epigenetic events, which comprise post-translational modifications of
histone tails or DNA methylation, control gene expression by altering chromatin structure …
histone tails or DNA methylation, control gene expression by altering chromatin structure …
The RNA N6-methyladenosine demethylase FTO promotes head and neck squamous cell carcinoma proliferation and migration by increasing CTNNB1
Y Zhang, L Chen, X Wu, Z Sun, F Wang… - … Journal of General …, 2021 - Taylor & Francis
Objective In this study, we aimed to investigate the role of RNA N6-methyladenosine
demethylase fat mass and obesity-associated protein (FTO) in head and neck squamous …
demethylase fat mass and obesity-associated protein (FTO) in head and neck squamous …