The intercalated disc (ID) is a highly specialized structure that connects cardiomyocytes via
mechanical and electrical junctions. Although described in some detail by light microscopy …

Connexins are assembled into dodecamer intercellular channels, a collection of which is
termed a gap junction, and their canonical function allowing direct exchange of ions and …

BACKGROUND: Heart failure causes changes in Cx43 (Connexin43) regulation that are
associated with arrhythmic heart disease. Pyk2 (proline-rich tyrosine kinase 2) is activated in …

Cardiac arrhythmia occurs frequently worldwide, and in severe cases can be fatal.
Mitochondria are the power plants of cardiomyocytes. In recent studies, mitochondria under …

Disruption of blood-testis barrier (BTB) was a crucial pathological feature of diabetes
induced-testicular injury at early phase. Aucubin (AU), a main active component in …

Myocardial infarction (MI) is one of the leading causes of death in the developed world, and
the loss of cardiomyocytes plays a critical role in the pathogenesis of heart failure. Implicated …

Background Diabetic cardiomyopathy (DCM) is a complex multifaceted disease responsible
for elevated heart failure (HF) morbidity and mortality in patients with diabetes mellitus (DM) …

Physiological and pathological processes such as homeostasis, embryogenesis,
development, tumorigenesis, and cell movement depend on the intercellular communication …

Gap junctions are specialized regions of the plasma membrane containing clusters of
channels that provide for the diffusion of ions and small molecules between adjacent cells. A …

BACKGROUND: Increased mitochondrial Ca2+ uptake has been implicated in the QT
prolongation and lethal arrhythmias associated with nonischemic cardiomyopathy. We …