Adenosine receptors modulate neuronal and synaptic function in a range of ways that may
make them relevant to the occurrence, development and treatment of brain ischemic …

This review summarizes recent developments that have contributed to understand how
adenosine receptors, particularly A2A receptors, modulate brain injury in various animal …

1 A degree of ambiguity and uncertainty exists concerning the distribution of mRNAs
encoding the four cloned adenosine receptors. In order to consolidate and extend current …

Extracellular adenosine critically modulates ischemic brain injury, at least in part through
activation of the A1 adenosine receptor. However, the role played by the A2A receptor has …

The distribution, molecular structure and role of adenosine A2 receptors in the nervous
system, is reviewed. The adenosine A2a receptor subtype, identified in the nervous system …

Delayed or secondary neuronal damage following traumatic injury to the central nervous
system (CNS) may result from pathologic changes in the brain's endogenous neurochemical …

It is well established that in the CNS, endogenous adenosine plays a pivotal role in
neurodegeneration. A low, nanomolar concentration of adenosine is normally present in the …

We have characterized the in vitro pharmacological profile of the new potent and selective
A2a adenosine receptor antagonist SCH 58261 [7-(2-phenylethyl)-5-amino-2-(2-furyl) …

The influence of CGS 21680, an adenosine A2A receptor agonist, on striatal glutamate
extracellular levels was tested in a microdialysis study in rats. CGS 21680 (10 μM), infused …

Numerous studies have consistently shown that agonist stimulation of adenosine A1
receptors results in a significant reduction of morbidity and mortality associated with global …