Adenosine receptors and neurological disease: neuroprotection and neurodegeneration
Adenosine receptors modulate neuronal and synaptic function in a range of ways that may
make them relevant to the occurrence, development and treatment of brain ischemic …
make them relevant to the occurrence, development and treatment of brain ischemic …
Adenosine A2A receptors and brain injury: broad spectrum of neuroprotection, multifaceted actions and “fine tuning” modulation
This review summarizes recent developments that have contributed to understand how
adenosine receptors, particularly A2A receptors, modulate brain injury in various animal …
adenosine receptors, particularly A2A receptors, modulate brain injury in various animal …
Tissue distribution of adenosine receptor mRNAs in the rat
AK Dixon, AK Gubitz, DJS Sirinathsinghji… - British journal of …, 1996 - Wiley Online Library
1 A degree of ambiguity and uncertainty exists concerning the distribution of mRNAs
encoding the four cloned adenosine receptors. In order to consolidate and extend current …
encoding the four cloned adenosine receptors. In order to consolidate and extend current …
A2A adenosine receptor deficiency attenuates brain injury induced by transient focal ischemia in mice
JF Chen, Z Huang, J Ma, JM Zhu… - Journal of …, 1999 - Soc Neuroscience
Extracellular adenosine critically modulates ischemic brain injury, at least in part through
activation of the A1 adenosine receptor. However, the role played by the A2A receptor has …
activation of the A1 adenosine receptor. However, the role played by the A2A receptor has …
Adenosine A2 receptor-mediated excitatory actions on the nervous system
AM Sebastiao, JA Ribeiro - Progress in neurobiology, 1996 - Elsevier
The distribution, molecular structure and role of adenosine A2 receptors in the nervous
system, is reviewed. The adenosine A2a receptor subtype, identified in the nervous system …
system, is reviewed. The adenosine A2a receptor subtype, identified in the nervous system …
Novel pharmacologic therapies in the treatment of experimental traumatic brain injury: a review
TK McINTOSH - Journal of neurotrauma, 1993 - liebertpub.com
Delayed or secondary neuronal damage following traumatic injury to the central nervous
system (CNS) may result from pathologic changes in the brain's endogenous neurochemical …
system (CNS) may result from pathologic changes in the brain's endogenous neurochemical …
[PDF][PDF] Neuroprotective role of adenosine in the CNS
J Wardas - Polish journal of pharmacology, 2002 - Citeseer
It is well established that in the CNS, endogenous adenosine plays a pivotal role in
neurodegeneration. A low, nanomolar concentration of adenosine is normally present in the …
neurodegeneration. A low, nanomolar concentration of adenosine is normally present in the …
The non-xanthine heterocyclic compound SCH 58261 is a new potent and selective A2a adenosine receptor antagonist.
C Zocchi, E Ongini, A Conti, A Monopoli… - … of Pharmacology and …, 1996 - ASPET
We have characterized the in vitro pharmacological profile of the new potent and selective
A2a adenosine receptor antagonist SCH 58261 [7-(2-phenylethyl)-5-amino-2-(2-furyl) …
A2a adenosine receptor antagonist SCH 58261 [7-(2-phenylethyl)-5-amino-2-(2-furyl) …
Adenosine A2A receptor stimulation enhances striatal extracellular glutamate levels in rats
P Popoli, P Betto, R Reggio, G Ricciarello - European journal of …, 1995 - Elsevier
The influence of CGS 21680, an adenosine A2A receptor agonist, on striatal glutamate
extracellular levels was tested in a microdialysis study in rats. CGS 21680 (10 μM), infused …
extracellular levels was tested in a microdialysis study in rats. CGS 21680 (10 μM), infused …
Adenosine and cerebral ischemia: therapeutic future or death of a brave concept?
DKJE Von Lubitz - European journal of pharmacology, 1999 - Elsevier
Numerous studies have consistently shown that agonist stimulation of adenosine A1
receptors results in a significant reduction of morbidity and mortality associated with global …
receptors results in a significant reduction of morbidity and mortality associated with global …