Cutaneous melanoma (CM) is a malignant tumor formed from pigment-producing cells
called melanocytes. It is one of the most aggressive and fatal forms of skin malignancy. In …

The main cause of death in melanoma patients is widespread metastases. Staging of
melanoma is based on the primary tumor thickness, ulceration, lymph node and distant …

Melanin possess radioprotective and scavenging properties, and its presence can affect the
behavior of melanoma cells, its surrounding environment and susceptibility to the therapy …

Ultraviolet B (UVB), in addition to having carcinogenic activity, is required for the production
of vitamin D3 (D3) in the skin which supplies> 90% of the body's requirement. Vitamin D is …

The incidence of cutaneous malignant melanoma has rapidly increased in recent years in all
parts of the world, and melanoma is a leading cause of cancer death. As even relatively …

Background: The incidence of malignant melanoma is increasing faster than that for any
other cancer. Histological examination of skin excision biopsies remains the standard …

Melanoma, a cancer that arises from melanocytes is one of the most unresponsive cancers
to known therapies. Several studies showed encouraging results of the efficacy of …

High mortality rate for metastatic melanoma is related to its resistant to the current methods
of therapy. Melanogenesis is a metabolic pathway characteristic for normal and malignant …

Melanoma represents a significant clinical problem affecting a large segment of the
population with a relatively high incidence and mortality rate. Ultraviolet radiation (UVR) is …

The SLC45A2 gene encodes a Membrane-Associated Transporter Protein (MATP).
Mutations of this gene cause oculocutaneous albinism type 4 (OCA4). However, the …