Cells in tissues experience a plethora of forces that regulate their fate and modulate
development and homeostasis. Cells sense mechanical cues through localized …

The development of the vertebrate eyes is a complex process starting from anterior-posterior
and dorso-ventral patterning of the anterior neural tube, resulting in the formation of the eye …

Understanding human organ formation is a scientific challenge with far-reaching medical
implications,. Three-dimensional stem-cell cultures have provided insights into human cell …

INTRODUCTION Vertebrate development comprises multiple complex morphogenetic
processes that shape the embryonic body plan through self-organization of pluripotent stem …

Neural tube (NT) defects arise from abnormal neurulation and result in the most common
birth defects worldwide. Yet, mechanisms of primate neurulation remain largely unknown …

During development, both cells and tissues must acquire the correct shape to allow their
proper function. This is especially relevant in the nervous system, where the shape of …

The emergence of the three germ layers and the lineage-specific precursor cells
orchestrating organogenesis represent fundamental milestones during early embryonic …

Integrated in vitro models of human organogenesis are needed to elucidate the multi-
systemic events underlying development and disease. Here we report the generation of …

Although understanding how soluble cues direct cellular processes revolutionised the study
of cell biology in the second half of the 20th century, over the last two decades, new insights …

Human structural congenital malformations are the leading cause of infant mortality in the
United States. Estimates from the United States Center for Disease Control and Prevention …