[HTML][HTML] The ST2/IL-33 axis in immune cells during inflammatory diseases
B Griesenauer, S Paczesny - Frontiers in immunology, 2017 - frontiersin.org
Il1rl1 (also known as ST2) is a member of the IL-1 superfamily, and its only known ligand is
IL-33. ST2 exists in two forms as splice variants: a soluble form (sST2), which acts as a …
IL-33. ST2 exists in two forms as splice variants: a soluble form (sST2), which acts as a …
The development and in vivo function of T helper 9 cells
The specialized cytokine secretion profiles of T helper (TH) cells are the basis for a focused
and efficient immune response. On the twentieth anniversary of the first descriptions of the …
and efficient immune response. On the twentieth anniversary of the first descriptions of the …
A phenotypically and functionally distinct human TH2 cell subpopulation is associated with allergic disorders
E Wambre, V Bajzik, JH DeLong, K O'Brien… - Science translational …, 2017 - science.org
Allergen-specific type 2 helper T (TH2) cells play a central role in initiating and orchestrating
the allergic and asthmatic inflammatory response pathways. One major factor limiting the …
the allergic and asthmatic inflammatory response pathways. One major factor limiting the …
[HTML][HTML] T cell subsets in graft versus host disease and graft versus tumor
Allogeneic hematopoietic cell transplantation (allo-HCT) is an essential therapeutic modality
for patients with hematological malignancies and other blood disorders. Unfortunately, acute …
for patients with hematological malignancies and other blood disorders. Unfortunately, acute …
TH9 cells that express the transcription factor PU.1 drive T cell–mediated colitis via IL-9 receptor signaling in intestinal epithelial cells
K Gerlach, YY Hwang, A Nikolaev, R Atreya… - Nature …, 2014 - nature.com
The molecular checkpoints that drive inflammatory bowel diseases are incompletely
understood. Here we found more T cells expressing the transcription factor PU. 1 and …
understood. Here we found more T cells expressing the transcription factor PU. 1 and …
Sounding the alarmins—the role of alarmin cytokines in asthma
GM Gauvreau, C Bergeron, LP Boulet, DW Cockcroft… - Allergy, 2023 - Wiley Online Library
The alarmin cytokines thymic stromal lymphopoietin (TSLP), interleukin (IL)‐33, and IL‐25
are epithelial cell‐derived mediators that contribute to the pathobiology and …
are epithelial cell‐derived mediators that contribute to the pathobiology and …
Th9 cells: differentiation and disease
MH Kaplan - Immunological reviews, 2013 - Wiley Online Library
CD 4+ T‐helper cells regulate immunity and inflammation through the acquisition of
potential to secrete specific cytokines. The acquisition of cytokine‐secreting potential, in a …
potential to secrete specific cytokines. The acquisition of cytokine‐secreting potential, in a …
Th9 cells, new players in adaptive immunity
Upon antigen-specific stimulation, naïve CD4+ T cells have the potential to differentiate into
various T helper (Th) cell subsets. Earlier models of Th cell differentiation focused on IFN-γ …
various T helper (Th) cell subsets. Earlier models of Th cell differentiation focused on IFN-γ …
The IL-1 family in tumorigenesis and antitumor immunity
The IL-1 family of cytokines consists of IL-1α, IL-1β, IL-18, IL-33, IL-36α, IL-36β, and IL-36γ.
These proteins form four signaling receptor complexes: the IL-1 receptor (IL-1R1 and IL …
These proteins form four signaling receptor complexes: the IL-1 receptor (IL-1R1 and IL …
[HTML][HTML] Pleiotropic Effects of IL-33 on CD4+ T Cell Differentiation and Effector Functions
F Alvarez, JH Fritz, CA Piccirillo - Frontiers in immunology, 2019 - frontiersin.org
IL-33, a member of the IL-1 family of cytokines, was originally described in 2005 as a
promoter of type 2 immune responses. However, recent evidence reveals a more complex …
promoter of type 2 immune responses. However, recent evidence reveals a more complex …