The airway surface liquid (ASL) is a thin sheet of fluid that covers the luminal aspect of the
airway epithelium. The ASL is a site of several first-line host defenses, and its composition is …

The conjunctival epithelium covering the eye contains two main cell types: mucus-producing
goblet cells and water-secreting keratinocytes, which present mucins on their apical surface …

Chloride is the most abundant inorganic anions in almost all cells and in human circulation
systems. Its homeostasis is therefore important for systems physiology and normal cellular …

Dysfunction of the cystic fibrosis transmembrane conductance regulator (CFTR) anion
channel by genetic mutations causes the inherited disease cystic fibrosis (CF). CF lung …

When activated by increase in intracellular Ca 2+, anoctamins (TMEM16 proteins) operate
as phospholipid scramblases and as ion channels. Anoctamin 1 (ANO1) is the Ca 2+ …

When activated by increase in intracellular Ca2+, anoctamins (TMEM16 proteins) operate as
phospholipid scramblases and as ion channels. Anoctamin 1 (ANO1) is the Ca2+-activated …

The respiratory tract possesses a highly regulated innate defense system which includes
efficient cilia-mediated mucus transport or mucociliary clearance (MCC). This essential …

Ion and fluid transport are critical for the functioning of epithelial tissues affected in cystic
fibrosis (CF), such as those lining the airways, pancreatic and biliary ducts, intestines and …

Cystic fibrosis (CF) is one of the inherited autosomal recessive disorders with very
complicated pathogenesis. Identifying the molecular signatures and specific biomarkers of …

Cystic Fibrosis (CF) is the most common, severe, autosomal recessive disease in the
Caucasian population, and is caused by mutations in the cystic fibrosis transmembrane …