[HTML][HTML] Immunogenicity and protective efficacy of influenza a DNA vaccines encoding artificial antigens based on conservative hemagglutinin stem region and M2 …
S Bazhan, D Antonets, E Starostina, T Ilyicheva… - Vaccines, 2020 - mdpi.com
Background: Development of a universal vaccine capable to induce antibody responses
against a broad range of influenza virus strains attracts growing attention. Hemagglutinin …
against a broad range of influenza virus strains attracts growing attention. Hemagglutinin …
Phase 1 randomized, placebo-controlled, dose-escalating study to evaluate OVX836, a nucleoprotein-based influenza vaccine: intramuscular results
K Withanage, I De Coster, N Cools… - The Journal of …, 2022 - academic.oup.com
Background OVX836 is a recombinant protein vaccine targeting the highly conserved
influenza nucleoprotein (NP), which could confer broad-spectrum protection against this …
influenza nucleoprotein (NP), which could confer broad-spectrum protection against this …
Current challenges: from the path of “original antigenic sin” towards the development of universal flu vaccines: flu vaccine efficacy encounters significant hurdles from …
Annual flu led by influenza viruses is contemplated to be one of the foremost global health
challenges due to its rapid spread leading to the life-threatening epidemic or pandemic. An …
challenges due to its rapid spread leading to the life-threatening epidemic or pandemic. An …
[HTML][HTML] Immunopeptidomic analysis of influenza A virus infected human tissues identifies internal proteins as a rich source of HLA ligands
CD8+ and CD4+ T cells provide cell-mediated cross-protection against multiple influenza
strains by recognising epitopes bound as peptides to human leukocyte antigen (HLA) class I …
strains by recognising epitopes bound as peptides to human leukocyte antigen (HLA) class I …
Single-component multilayered self-assembling protein nanoparticles displaying extracellular domains of matrix protein 2 as a pan-influenza A vaccine
The development of a cross-protective pan-influenza A vaccine remains a significant
challenge. In this study, we designed and evaluated single-component self-assembling …
challenge. In this study, we designed and evaluated single-component self-assembling …
Universal influenza vaccine based on conserved antigens provides long-term durability of immune responses and durable broad protection against diverse challenge …
CY Lo, JA Misplon, X Li, GE Price, Z Ye, SL Epstein - Vaccine, 2021 - Elsevier
Current influenza vaccines rely on inducing antibody responses to the rapidly evolving
hemagglutinin (HA) and neuraminidase (NA) proteins, and thus need to be strain-matched …
hemagglutinin (HA) and neuraminidase (NA) proteins, and thus need to be strain-matched …
[HTML][HTML] Systemic and respiratory T-cells induced by seasonal H1N1 influenza protect against pandemic H2N2 in ferrets
K van de Ven, F de Heij, H van Dijken… - Communications …, 2020 - nature.com
Traditional influenza vaccines primarily induce a narrow antibody response that offers no
protection against heterosubtypic infections. Murine studies have shown that T cells can …
protection against heterosubtypic infections. Murine studies have shown that T cells can …
[HTML][HTML] Understanding the role of HLA class I molecules in the immune response to influenza infection and rational design of a peptide-based vaccine
Influenza A virus is a respiratory pathogen that is responsible for regular epidemics and
occasional pandemics that result in substantial damage to life and the economy. The yearly …
occasional pandemics that result in substantial damage to life and the economy. The yearly …
[HTML][HTML] Structural basis of biased T cell receptor recognition of an immunodominant HLA-A2 epitope of the SARS-CoV-2 spike protein
CD8+ T cells play an important role in vaccination and immunity against severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Although numerous SARS …
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Although numerous SARS …
Anomalous influenza seasonality in the United States and the emergence of novel influenza B viruses
RK Borchering, CE Gunning… - Proceedings of the …, 2021 - National Acad Sciences
The 2019/2020 influenza season in the United States began earlier than any season since
the 2009 H1N1 pandemic, with an increase in influenza-like illnesses observed as early as …
the 2009 H1N1 pandemic, with an increase in influenza-like illnesses observed as early as …