The epithelial–mesenchymal plasticity landscape: Principles of design and mechanisms of regulation
Epithelial–mesenchymal plasticity (EMP) enables cells to interconvert between several
states across the epithelial–mesenchymal landscape, thereby acquiring hybrid epithelial …
states across the epithelial–mesenchymal landscape, thereby acquiring hybrid epithelial …
Induction of metastasis, cancer stem cell phenotype, and oncogenic metabolism in cancer cells by ionizing radiation
SY Lee, EK Jeong, MK Ju, HM Jeon, MY Kim, CH Kim… - Molecular cancer, 2017 - Springer
Radiation therapy is one of the major tools of cancer treatment, and is widely used for a
variety of malignant tumours. Radiotherapy causes DNA damage directly by ionization or …
variety of malignant tumours. Radiotherapy causes DNA damage directly by ionization or …
Cancer stem cells: The root of tumor recurrence and metastases
C Peitzsch, A Tyutyunnykova, K Pantel… - Seminars in cancer …, 2017 - Elsevier
Metastatic tumors are the cause of more than 90% of cancer related deaths. Metastasis
formation can be considered as a culmination of the Darwinian evolutionary process within …
formation can be considered as a culmination of the Darwinian evolutionary process within …
Fatty acid synthase (FASN) as a therapeutic target in breast cancer
JA Menendez, R Lupu - Expert opinion on therapeutic targets, 2017 - Taylor & Francis
Introduction: Ten years ago, we put forward the metabolo-oncogenic nature of fatty acid
synthase (FASN) in breast cancer. Since the conception of this hypothesis, which provided a …
synthase (FASN) in breast cancer. Since the conception of this hypothesis, which provided a …
Role of metabolic reprogramming in epithelial–mesenchymal transition (EMT)
Activation of epithelial–mesenchymal transition (EMT) is thought to be an essential step for
cancer metastasis. Tumor cells undergo EMT in response to a diverse range of extra-and …
cancer metastasis. Tumor cells undergo EMT in response to a diverse range of extra-and …
[HTML][HTML] Fatty acid synthase–modern tumor cell biology insights into a classical oncology target
D Buckley, G Duke, TS Heuer, M O'Farrell… - Pharmacology & …, 2017 - Elsevier
Decades of preclinical and natural history studies have highlighted the potential of fatty acid
synthase (FASN) as a bona fide drug target for oncology. This review will highlight the …
synthase (FASN) as a bona fide drug target for oncology. This review will highlight the …
Animal fatty acid synthase: a chemical nanofactory
Fatty acids are crucial molecules for most living beings, very well spread and conserved
across species. These molecules play a role in energy storage, cell membrane architecture …
across species. These molecules play a role in energy storage, cell membrane architecture …
Stabilization of FASN by ACAT1-mediated GNPAT acetylation promotes lipid metabolism and hepatocarcinogenesis
Metabolic alteration for adaptation of the local environment has been recognized as a
hallmark of cancer. GNPAT dysregulation has been implicated in hepatocellular carcinoma …
hallmark of cancer. GNPAT dysregulation has been implicated in hepatocellular carcinoma …
Dormant disseminated tumor cells and cancer stem/progenitor-like cells: Similarities and opportunities
Distant recurrences occurring years after removal of the primary tumor arise from
disseminated tumor cells (DTCs) that lie dormant (quiescent/asymptomatic) until they …
disseminated tumor cells (DTCs) that lie dormant (quiescent/asymptomatic) until they …
[HTML][HTML] Targeting lipid metabolism in the treatment of ovarian cancer
S Chaudhry, SN Thomas, GE Simmons Jr - Oncotarget, 2022 - ncbi.nlm.nih.gov
Cancer cells undergo alterations in lipid metabolism to support their high energy needs,
tumorigenesis and evade an anti-tumor immune response. Alterations in fatty acid …
tumorigenesis and evade an anti-tumor immune response. Alterations in fatty acid …