Background: Ovarian malignant tumours are rarely diagnosed in adolescents but may have
a significant impact on their survival, future fertility and quality of life. The management of …

Menopausal transition entails a progressive decrease in hormone production by the ovaries
that lead to important physical and psychological changes that could significantly affect …

Oncology treatments cause infertility, and ovarian tissue cryopreservation and
transplantation (OTCT) is the only option for fertility preservation in prepubertal girls with …

Objective: This study investigated the effects of a vitrification/warming procedure on the
mRNA transcriptome of human ovarian tissues. Design: Human ovarian tissues were …

Fertility preservation (FP) in pediatric and adolescent oncology patients presents a complex
interplay between cancer treatment imperatives and reproductive aspirations, demanding a …

The method of immersion optical clearing reduces light scattering in tissues, which improves
the use of optical technologies in the practice of clinicians. In this work, we studied the …

Ovarian tissue has a unique microarchitecture and a complex cellular and molecular
dynamics that are essential for follicular survival and development. Due to this great …

Purpose Ovarian tissue cryopreservation is vital for fertility preservation, yet its effect on
ovarian tissue follicle survival and transcriptomic signature requires further investigation …

Abstract Background and Aims As survival rates in childhood cancer progress significantly,
health outcomes in adulthood are pivotal to quality of life (QoL). Female patients undergoing …

Background: The majority of female cancer patients undergoing anticancer treatments are at
risk of experiencing 'cancer treatment-related infertility', which can result in permanent …