Growing global burden of type 1 diabetes needs multitiered precision public health interventions

SJ Guo, H Shao - The Lancet Diabetes & Endocrinology, 2022 - thelancet.com
Diabetes is a public health crisis, and diabetes-related health and economic burdens have
been rising globally over the past decades, with the growth being the most striking in low …

Targeting α-amylase enzyme through multi-fold structure-based virtual screening and molecular dynamic simulation

SA Halim, HW Lodhi, M Waqas, A Khalid… - Journal of …, 2023 - Taylor & Francis
Abstract α-Amylase play important role in hydrolyses of α-bonds of large α-linked
polysaccharides; thus, it is a potential drug target in diabetes mellites (DM) and its inhibition …

Safety event outcomes and glycemic control with a hybrid closed-loop system used by Chinese adolescents and adults with type 1 diabetes mellitus

Y Pei, W Ke, J Lu, Y Lin, Z Zhang, Y Peng… - Diabetes Technology …, 2023 - liebertpub.com
Background: While evidence supports glycemic control benefits for individuals with type 1
diabetes mellitus (T1DM) using hybrid closed-loop (HCL) systems, HCL automated insulin …

A plan to improve global type 1 diabetes epidemiology data

D Beran, K Højlund, S Besançon, ML Mundt… - The Lancet Diabetes & …, 2023 - thelancet.com
The discovery and subsequent introduction of insulin therapy in 1922 led to fundamental
changes in the treatment and epidemiology of type 1 diabetes. In Boston, MA, USA, the life …

The immunology of type 1 diabetes

KC Herold, T Delong, AL Perdigoto, N Biru… - Nature Reviews …, 2024 - nature.com
Following the seminal discovery of insulin a century ago, treatment of individuals with type 1
diabetes (T1D) has been largely restricted to efforts to monitor and treat metabolic glucose …

[HTML][HTML] Incident cardiovascular-kidney disease, diabetic ketoacidosis, hypoglycaemia and mortality in adult-onset type 1 diabetes: a population-based retrospective …

Y Fan, ESH Lau, H Wu, A Yang, E Chow… - The Lancet Regional …, 2023 - thelancet.com
Background Type 1 diabetes can occur at any age. The majority of literature on type 1
diabetes were reported in children whereas adult-onset type 1 diabetes is less well …

Type 1 diabetes and inborn errors of immunity: Complete strangers or 2 sides of the same coin?

G Mancuso, CB Genzano, A Fierabracci… - Journal of Allergy and …, 2023 - Elsevier
Type 1 diabetes (T1D) is a polygenic disease and does not follow a mendelian pattern.
Inborn errors of immunity (IEIs), on the other hand, are caused by damaging germline …

Fat‐to‐muscle ratio is associated with insulin resistance and cardiometabolic disorders in adults with type 1 diabetes mellitus

F Huang, X Ji, Z Wang, Y Yin, L Fan, J Li… - Diabetes, Obesity …, 2023 - Wiley Online Library
Aims This study aimed to investigate the correlation of the fat‐to‐muscle ratio (FMR) with
insulin resistance (IR) and cardiometabolic disorders (CMD) in patients with type 1 diabetes …

Teplizumab: Promises and challenges of a recently approved monoclonal antibody for the prevention of type 1 diabetes or preservation of residual beta cell function

NM Fanaropoulou, GC Tsatsani… - Expert Review of …, 2024 - Taylor & Francis
ABSTRACT Introduction Type 1 diabetes (T1D) is a chronic autoimmune endocrinopathy
with increasing incidence that results in the depletion of pancreatic beta cells and …

Type 1 diabetes impairs endothelium-dependent relaxation via increasing endothelial cell glycolysis through advanced glycation end products, PFKFB3, and Nox1 …

RT Atawia, RK Batori, CR Jordan, S Kennard… - …, 2023 - Am Heart Assoc
BACKGROUND: Type 1 diabetes (T1D) is a major cause of endothelial dysfunction.
Although cellular bioenergetics has been identified as a new regulator of vascular function …