Hematopoietic stem cells (HSCs) exist in a constant steady state, balancing selfrenewal with
proliferative gene expression programs in response to various cellintrinsic and-extrinsic …

Dysregulation of biological processes in normal cells can lead to the abnormal growth of
tumours. Oncogenesis requires the acquisition of advantageous mutations to expand in a …

Bei der Myelofibrose wird blutproduzierendes Knochenmark durch die Einlagerung von
extrazellulären Matrixproteinen (ECM) durch fibrotisches Gewebe ersetzt. Der Auslöser ist …

Hematopoiesis is dynamically controlled by an epigenetic landscape that regulates gene
transcription. Ten-eleven translocation 2 (TET2) is a Fe 2+ and α-ketoglutarate (α-KG) …

Hyperglycaemia in diabetes mellitus participates in the development of endothelial
dysfunction, which typically precedes cardiovascular diseases. This hyperglycaemiainduced …

Classical BCR-ABL-negative myeloproliferative neoplasms (MPN) include polycythaemia
vera, essential thrombocythaemia, and primary myelofibrosis. Unlike monogenic disorders …

Myelodysplastic Syndromes (MDS) are heterogeneous bone marrow (BM) failure
malignancies characterized by constitutive innate immune activation, NLRP3 inflammasome …

Myeloproliferative neoplasms (MPNs), such as polycythemia vera (PV), essential
thrombocythemia (ET), and primary myelofibrosis (MF), are hematologic disorders that have …

The generation of class switched antibodies and mounting of an affinity-matured antibody
response requires rearrangement of germline DNA to allow expression of non-IgM/IgD …

Background As DNA demethylation protein, Ten-eleven translocation 1 (TET1) has been
widely reported that is related to tumorigenesis and tumor metastasis. This study is to …