Abstract Background/Aims: On behalf of the Drug and Therapeutics, and Ethics Committees
of the Pediatric Endocrine Society, we sought to update the guidelines published in 2003 on …

Objective: Low birth weight remains a major cause of morbidity and mortality in early infancy
and childhood. It is associated with an increased risk of health problems later in life …

Objective: The development of these guidelines is sponsored by the American Association
of Clinical Endocrinologists (AACE) Board of Directors and American College of …

Puberty is a period of development characterized by partially concurrent changes which
includes growth acceleration, alteration in body composition and appearance of secondary …

The cure rate for paediatric malignancies is increasing, and most patients who have cancer
during childhood survive and enter adulthood. Surveillance for late endocrine effects after …

Measurement of the serum concentration of insulin-like growth factor-1 (IGF-I) is generally
used as a screening investigation for disorders of the growth hormone (GH)/IGF-I axis in …

The diagnosis of GH deficiency (GHD) in childhood is a multistep process involving clinical
history, examination with detailed auxology, biochemical testing, and pituitary imaging, with …

Context: GH and IGF-1 have been shown to affect tumor growth in vitro and in some animal
models. This report summarizes the available evidence on whether GH therapy in childhood …

Key Clinical Points Short Stature in Childhood Thorough evaluation of short stature in
childhood is warranted when the child's height deficit is severe (< 1st percentile for age), the …

Background Children born small for gestational age (SGA) experience higher rates of
morbidity and mortality than those born appropriate for gestational age. In Latin America …