In vitro and in vivo aspects of cascade impactor tests and inhaler performance: a review

J Mitchell, S Newman, HK Chan - Aaps Pharmscitech, 2007 - Springer
The purpose of this review is to discuss the roles of cascade impactor (CI) data in inhaler
assessment and to examine the relationship between aerodynamic particle size distribution …

Clinical experimentation with aerosol antibiotics: current and future methods of administration

P Zarogoulidis, I Kioumis, K Porpodis… - Drug design …, 2013 - Taylor & Francis
Currently almost all antibiotics are administered by the intravenous route. Since several
systems and situations require more efficient methods of administration, investigation and …

[图书][B] Pharmaceutical inhalation aerosol technology

AJ Hickey - 2003 - taylorfrancis.com
This thoroughly revised and expanded reference provides authoritative discussions on the
physiologic, pharmacologic, metabolic, molecular, cellular and physicochemical factors …

Medication nebulizer performance: effects of diluent volume, nebulizer flow, and nebulizer brand

D Hess, D Fisher, P Williams, S Pooler, RM Kacmarek - Chest, 1996 - Elsevier
Background Medication nebulizers are commonly used to delivery aerosolized medications
to patients with respiratory disease. We evaluated output and respirable aerosol available to …

Delivery of albuterol and ipratropium bromide from two nebulizer systems in chronic stable asthma: efficacy and pulmonary deposition

MA Johnson, SP Newman, R Bloom, N Talaee… - Chest, 1989 - Elsevier
Bronchodilator responses to both nebulized albuterol (salbutamol) and ipratropium bromide
and aerosol delivery to the tracheobronchial tree have been assessed in eight patients with …

Selecting and using nebuliser equipment

AH Kendrick, EC Smith, RS Wilson - Thorax, 1997 - ncbi.nlm.nih.gov
Aim of nebuliser therapy when determining the fill volume required to deliver a drug to a
patient. 9 The aim of nebuliser therapy is to deliver a therapeutic dose of the desired drug in …

Effect of aerosol particle size on bronchodilatation with nebulised terbutaline in asthmatic subjects.

MM Clay, D Pavia, SW Clarke - Thorax, 1986 - thorax.bmj.com
The bronchodilatation achieved by the beta 2 agonist terbutaline sulphate given as
nebulised aerosol from different devices has been measured in seven patients with mild …

Comparative study of budesonide as a nebulized suspension vs pressurized metered-dose inhaler in adult asthmatics

H Bisgaard, K Nikander, E Munch - Respiratory medicine, 1998 - Elsevier
The study objective was to compare the effect of budesonide administered as a nebulized
suspension as compared to a spray with a spacer in adult asthmatics. In a double-blind …

Effect of nebulised aerosol size on lung deposition in patients with mild asthma.

MM Clay, SW Clarke - Thorax, 1987 - thorax.bmj.com
A radioaerosol technique has been used to investigate whether the size distribution of
aerosols released from a jet nebuliser affects the amount of aerosol delivered to the lungs …

Inhaled drugs and the lung.

A Summers - Clinical & Experimental Allergy, 1991 - search.ebscohost.com
This article attempts to summarize the factors that influence drug deposition, retention and
absorption within the lung, concentrating particularly on therapeutic aerosols rather than …