In the digestive tract, there is evidence for the presence of high amounts of
endocannabinoids (anandamide and 2-arachidonylglycerol) and of mechanisms for …

The direct blockade of CB 1 cannabinoid receptors produces therapeutic effects as well as
adverse side-effects that limit their clinical potential. CB 1 negative allosteric modulators …

The effect of the cannabinoid (CB) receptor agonist WIN 55,212-2 on gastric acid secretion
was studied in the anaesthetized rat after stimulation with pentagastrin. WIN 55,212-2 (0.5–2 …

Since activation of cannabinoid CB1 receptors inhibits gastrointestinal transit in the mouse,
this study analyzed the action of the cannabinoid receptor agonist methanandamide on …

Abstract Cannabinoid-1 (CB 1) receptors on myenteric neurons are involved in the
regulation of intestinal motility. Our aim was to investigate CB 1 receptor involvement in …

Background & aims. The notion that specific receptors account for the ability of natural and
synthetic cannabinoids to alter physiological functions, prompted this study aimed at …

The use of cannabinoids to treat gastrointestinal (GI) motor disorders has considerable
potential. However, it is not clear if tolerance to their actions develops peripherally, as it does …

The investigation of natural and synthetic cannabinoid ligands, including (−)-Δ9-
tetrahydrocannabinol, cannabinol, cannabidiol, HU-210, HU-211, CT3, CP 55,940, WIN …

While most of the studies concerning the role of cannabinoids on gastric motility have
focused the attention on the gastric emptying in in vivo animal models, there is little …

Background: Obesity and overweight affect more than half of the US population and are
associated with a number of diseases. Rimonabant, a cannabinoid receptor 1 blocker in the …