[HTML][HTML] Hippocampal transcriptomic analyses reveal the potential antiapoptotic mechanism of a novel anticonvulsant agent Q808 on pentylenetetrazol-induced …
X Li, N Liu, D Wu, S chang Li, Q Wang, D Zhang… - Biomedicine & …, 2024 - Elsevier
Brain apoptosis is one of the main causes of epileptogenesis. The antiapoptotic effect and
potential mechanism of Q808, an innovative anticonvulsant chemical, have never been …
potential mechanism of Q808, an innovative anticonvulsant chemical, have never been …
RNA sequencing demonstrates ex vivo neocortical transcriptomic changes induced by epileptiform activity in male and female mice
AJ Vaughan, LJ McMeekin, K Hine, IW Stubbs… - Eneuro, 2024 - eneuro.org
Seizures are generally associated with epilepsy but may also be a symptom of many other
neurological conditions. A hallmark of a seizure is the intensity of the local neuronal …
neurological conditions. A hallmark of a seizure is the intensity of the local neuronal …
Pharmacokinetic study of Q808 in rhesus monkey using liquid chromatography–tandem mass spectrometry
N Xiao, X Li, W Li, J Zhao, Y Li, L Wang - Frontiers in Pharmacology, 2024 - frontiersin.org
Background Q808 is a novel antiepileptic agent currently in development. In this study, we
established and validated a LC-MS/MS method for the quantification of Q808 in Rhesus …
established and validated a LC-MS/MS method for the quantification of Q808 in Rhesus …
[HTML][HTML] Effects of long-term administration of Q808 on hippocampal transcriptome in healthy rats
X Li, Q Wang, D Zhang, D Wu, N Liu… - Chemical and …, 2022 - jstage.jst.go.jp
Epilepsy treatment with antiepileptic drugs (AEDs) is usually requires for many years. Q808
is an innovative antiepileptic chemical. It exerts effective antiepileptic effect against various …
is an innovative antiepileptic chemical. It exerts effective antiepileptic effect against various …