Emerging roles of SIRT6 in human diseases and its modulators
The biological functions of sirtuin 6 (SIRT6; eg, deacetylation, defatty‐acylation, and mono‐
ADP‐ribosylation) play a pivotal role in regulating lifespan and several fundamental …
ADP‐ribosylation) play a pivotal role in regulating lifespan and several fundamental …
[HTML][HTML] Partitioning circadian transcription by SIRT6 leads to segregated control of cellular metabolism
Circadian rhythms are intimately linked to cellular metabolism. Specifically, the NAD+-
dependent deacetylase SIRT1, the founding member of the sirtuin family, contributes to …
dependent deacetylase SIRT1, the founding member of the sirtuin family, contributes to …
Sirtuins: guardians of mammalian healthspan
W Giblin, ME Skinner, DB Lombard - Trends in Genetics, 2014 - cell.com
The first link between sirtuins and longevity was made 15 years ago in yeast. These initial
studies sparked efforts by many laboratories working in diverse model organisms to …
studies sparked efforts by many laboratories working in diverse model organisms to …
[HTML][HTML] Sirtuin 6: linking longevity with genome and epigenome stability
Sirtuin 6 (SIRT6) has been in the spotlight of aging research because progeroid phenotypes
are associated with SIRT6 deficiency. SIRT6 has multiple molecular functions, including …
are associated with SIRT6 deficiency. SIRT6 has multiple molecular functions, including …
Sirtuins at a glance
T Nakagawa, L Guarente - Journal of cell science, 2011 - journals.biologists.com
Sirtuins are NAD-dependent deacetylases that are highly conserved from bacteria to human
and SIR2 was originally shown to extend lifespan in budding yeast (Imai et al., 2000; …
and SIR2 was originally shown to extend lifespan in budding yeast (Imai et al., 2000; …
The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun
NR Sundaresan, P Vasudevan, L Zhong, G Kim… - Nature medicine, 2012 - nature.com
Abnormal activation of insulin-like growth factor (IGF)-Akt signaling is implicated in the
development of various diseases, including heart failure. However, the molecular …
development of various diseases, including heart failure. However, the molecular …
[HTML][HTML] Sirtuins in glucose and lipid metabolism
Sirtuins are evolutionarily conserved protein, serving as nicotinamide adenine dinucleotide-
dependent deacetylases or adenosine diphosphate-ribosyltransferases. The mammalian …
dependent deacetylases or adenosine diphosphate-ribosyltransferases. The mammalian …
[HTML][HTML] Structure and biochemical functions of SIRT6
PW Pan, JL Feldman, MK Devries, A Dong… - Journal of Biological …, 2011 - ASBMB
SIRT6 is a member of the evolutionarily conserved sirtuin family of NAD+-dependent protein
deacetylases and functions in genomic stability and transcriptional control of glucose …
deacetylases and functions in genomic stability and transcriptional control of glucose …
[HTML][HTML] SIRT6 in aging, metabolism, inflammation and cardiovascular diseases
Z Guo, P Li, J Ge, H Li - Aging and disease, 2022 - ncbi.nlm.nih.gov
As an important NAD+-dependent enzyme, SIRT6 has received significant attention since its
discovery. In view of observations that SIRT6-deficient animals exhibit genomic instability …
discovery. In view of observations that SIRT6-deficient animals exhibit genomic instability …
Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion
P Zhang, B Tu, H Wang, Z Cao… - Proceedings of the …, 2014 - National Acad Sciences
In mammalian cells, tumor suppressor p53 plays critical roles in the regulation of glucose
metabolism, including glycolysis and oxidative phosphorylation, but whether and how p53 …
metabolism, including glycolysis and oxidative phosphorylation, but whether and how p53 …