The Major Histocompatibility Complex (MHC) locus encodes classical MHC class I and MHC
class II molecules and nonclassical MHC-I molecules. The architecture of these molecules is …

The advent in recent years of the application of tetrameric arrays of class I peptide–MHC
complexes now enables us to detect and study rare populations of antigen‐specific CD8+ T …

Tapasin is a glycoprotein critical for loading major histocompatibility complex (MHC) class I
molecules with high-affinity peptides. It functions within the multimeric peptide-loading …

Motivation: Receptor–ligand interactions play an important role in controlling many
biological systems. One prominent example is the binding of peptides to the major …

The development of immunological therapies that incorporate peptide antigens presented to
T cells by MHC proteins is a long sought-after goal, particularly for cancer, where mutated …

T cell-mediated immunity requires T cell receptor (TCR) cross-reactivity, the mechanisms
behind which remain incompletely elucidated. The αβ TCR A6 recognizes both the Tax …

CD1 antigens bind a variety of self and foreign lipid and glycolipid antigens for presentation
to CD1-restricted T cell receptors (TCRs). Here we report the crystal structure of human …

Little is known about the structure of major histocompatibility complex (MHC) molecules
outside of mammals. Only one class I molecule in the chicken MHC is highly expressed …

We examined interactions in a soluble tapasin (TPN)/HLA‐B* 0801 complex to gain
mechanistic insights into the functions of TPN. Results show that TPN acts as a chaperone …

HLA-G is a nonclassical major histocompatibility complex class I (MHC-I) molecule that is
primarily expressed at the fetal–maternal interface, where it is thought to play a role in …