[HTML][HTML] Use of poly ADP-ribose polymerase [PARP] inhibitors in cancer cells bearing DDR defects: the rationale for their inclusion in the clinic
Background DNA damage response (DDR) defects imply genomic instability and favor
tumor progression but make the cells vulnerable to the pharmacological inhibition of the …
tumor progression but make the cells vulnerable to the pharmacological inhibition of the …
Impact of DNA polymorphisms in key DNA base excision repair proteins on cancer risk
B Karahalil, VA Bohr… - Human & experimental …, 2012 - journals.sagepub.com
Genetic variation in DNA repair genes can modulate DNA repair capacity and may be
related to cancer risk. However, study findings have been inconsistent. Inheritance of variant …
related to cancer risk. However, study findings have been inconsistent. Inheritance of variant …
Association between single-nucleotide polymorphisms of selected genes involved in the response to DNA damage and risk of colon, head and neck, and breast …
K Jelonek, A Gdowicz-Kłosok, M Pietrowska… - Journal of applied …, 2010 - Springer
Single-nucleotide polymorphisms in genes involved in DNA-damage-induced responses
are reported frequently to be a risk factor in various cancer types. Here we analysed …
are reported frequently to be a risk factor in various cancer types. Here we analysed …
Genomic instability and the selection of treatments for cancer
SA Martin, M Hewish, CJ Lord… - The Journal of …, 2010 - Wiley Online Library
A critical link exists between DNA mutation and chromosomal rearrangements (genomic
instability) and cancer development. This genomic instability can manifest itself as small …
instability) and cancer development. This genomic instability can manifest itself as small …
DNA repair genes XPC, XPD, XRCC1, and XRCC3 are associated with risk and survival of squamous cell carcinoma of the head and neck
L Farnebo, A Stjernström, M Fredrikson, A Ansell… - DNA repair, 2015 - Elsevier
Head and neck squamous cell carcinomas (HNSCC) are a heterogenous group of tumors
with a high rate of early recurrences, second primary tumors, and mortality. Despite …
with a high rate of early recurrences, second primary tumors, and mortality. Despite …
[HTML][HTML] Direct and oxidative DNA damage in a group of painters exposed to VOCs: dose–response relationship
R Sisto, D Cavallo, CL Ursini, AM Fresegna… - Frontiers in public …, 2020 - frontiersin.org
Volatile organic compounds (VOCs) are present in several working activities. This work is
aimed at comparing oxidative stress and DNA damage biomarkers to specific VOCs in the …
aimed at comparing oxidative stress and DNA damage biomarkers to specific VOCs in the …
Associated risk of XRCC1 and XPD cross talk and life style factors in progression of head and neck cancer in north Indian population
A Kumar, MC Pant, HS Singh, S Khandelwal - … Research/Fundamental and …, 2012 - Elsevier
Effective DNA repair machinery ensures maintenance of genomic integrity. Environmental
insults, ageing and replication errors necessitate the need for proper DNA repair systems …
insults, ageing and replication errors necessitate the need for proper DNA repair systems …
Evaluation of XRCC1 gene polymorphism as a biomarker in head and neck cancer patients undergoing chemoradiation therapy
SS Nanda, AK Gandhi, M Rastogi, R Khurana… - International Journal of …, 2018 - Elsevier
Purpose We evaluated the correlation of the x-ray repair cross complementing gene 1
(XRCC1) Arg194Trp polymorphism with clinical outcomes in head and neck squamous cell …
(XRCC1) Arg194Trp polymorphism with clinical outcomes in head and neck squamous cell …
ERCC1 and XRCC1 as biomarkers for lung and head and neck cancer
A Vaezi, CH Feldman… - … and personalized medicine, 2011 - Taylor & Francis
Advanced stage non-small cell lung cancer and head and neck squamous cell carcinoma
are both treated with DNA damaging agents including platinum-based compounds and …
are both treated with DNA damaging agents including platinum-based compounds and …
Reduced expression of DNA repair genes (XRCC1, XPD, and OGG1) in squamous cell carcinoma of head and neck in North India
Squamous cell carcinoma of head and neck (SCCHN) is the sixth most common cancer
globally, and in India, it accounts for 30% of all cancer cases. Epidemiological studies have …
globally, and in India, it accounts for 30% of all cancer cases. Epidemiological studies have …