Sphingolipids play an important role in the development of diabetes, both type 1 and type 2
diabetes, as well as in the development of both micro-and macro-vascular complications …

Purpose Organoids are three-dimensional cultures of stem cells in an environment similar to
the body's extracellular matrix. This is also a novel development in the realm of regenerative …

Abstract Background The combination of Astragalus membranaceus and Salvia miltiorrhiza
(AS) is an effective prescription for treating diabetic kidney disease (DKD) in traditional …

Bariatric surgery induces significant microbial and metabolomic changes, however, links
between microbial and metabolic pathways have not been fully elucidated. The objective of …

Resveratrol (RSV) is a phenolic compound with strong antioxidant activity, which is
generally associated with the beneficial effects of wine on human health. All resveratrol …

Health effects induced by heavy metal components of particulate matter need further
research. A total of 32 healthy volunteers were recruited to walk for 4 h in two different …

Sphingolipids, which act as a bioactive signaling molecules, are involved in several cellular
processes such as cell survival, proliferation, migration and apoptosis. An imbalance in the …

Blueberry anthocyanin-rich extract (BAE) was supplemented to high-fat diet (HFD)-fed mice
to investigate sphingolipid metabolism modulating factors involved in the attenuated …

ABSTRACT Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that interacts via 5 G-
protein coupled receptors, S1PR1-5, to regulate signalling pathways critical to biological …

Introduction Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM) represent two
major chronic diseases that affect a large percentage of the population and share common …