Background Depressive disorder is often chronic and recurrent, and results in a heavy
psychosocial burden on the families of patients with this disorder. This study aims to …

A fundamental question in the medical management of disease is how well treatment works.
Although there are many ways of defining improvement, one endpoint of definite interest is …

More than a decade ago, a consensus panel recommended that remission be defined on
the 17-item version of the Hamilton Rating Scale for Depression (HAM-D) as a cutoff of less …

Predictors of depressive symptoms may differ before and after the first onset of major
depression due to stress sensitization. Dependent stressors, or those to which …

Objective: To review adverse outcomes following response in treatment of depression.
Method: Review of published literature with particular emphasis on key papers. Results …

BackgroundDespite a growing use of selective serotonin reuptake inhibitors in older people,
only one trial has examined their prophylactic efficacy in people aged 65 years and over …

Since its emergence as a medical discipline, and for over a century, psychiatry did not
involve the quantification of psychopathological phenomena. Fine extensive descriptions …

BACKGROUND: The risk of recurrence in depressive disorder is high and increases with the
number of episodes. We investigated whether individuals with a history of recurrent …

Depression is considered to be a major suicide precursor: An estimated 50% of those who
die through suicide have suffered from depression (Isometsä et al., 1998). Among those ever …

Background The Remission from Depression Questionnaire (RDQ) assesses multiple
domains considered by depressed patients to be relevant to the construct of remission. The …