Metabolic complications affecting adipose tissue, lipid and glucose metabolism associated with HIV antiretroviral treatment
C Lagathu, V Béréziat, J Gorwood… - Expert opinion on …, 2019 - Taylor & Francis
Introduction: Efficient antiretroviral-treatment (ART) generally allows control of HIV infection.
However, persons-living-with-HIV (PLWH), when aging, present a high prevalence of …
However, persons-living-with-HIV (PLWH), when aging, present a high prevalence of …
Lamin A/C: function in normal and tumor cells
N Dubik, S Mai - Cancers, 2020 - mdpi.com
Simple Summary The aim of this review is to summarize lamin A/C's currently known
functions in both normal and diseased cells. Lamin A/C is a nuclear protein with many …
functions in both normal and diseased cells. Lamin A/C is a nuclear protein with many …
Dunnigan lipodystrophy syndrome: French National Diagnosis and Care Protocol (PNDS; Protocole National de Diagnostic et de Soins)
H Mosbah, B Donadille, C Vatier, S Janmaat… - Orphanet Journal of …, 2022 - Springer
Abstract Dunnigan syndrome, or Familial Partial Lipodystrophy type 2 (FPLD2; ORPHA
2348), is a rare autosomal dominant disorder due to pathogenic variants of the LMNA gene …
2348), is a rare autosomal dominant disorder due to pathogenic variants of the LMNA gene …
The structural and gene expression hypotheses in laminopathic diseases—not so different after all
S Osmanagic-Myers, R Foisner - Molecular Biology of the Cell, 2019 - Am Soc Cell Biol
Laminopathies are a diverse group of rare diseases with various pathologies in different
tissues, which are linked to mutations in the LMNA gene. Historically, the structural disease …
tissues, which are linked to mutations in the LMNA gene. Historically, the structural disease …
Most myopathic lamin variants aggregate: A functional genomics approach for assessing variants of uncertain significance
CL Anderson, ER Langer, TC Routes… - NPJ Genomic …, 2021 - nature.com
Hundreds of LMNA variants have been associated with several distinct disease phenotypes.
However, genotype–phenotype relationships remain largely undefined and the impact for …
However, genotype–phenotype relationships remain largely undefined and the impact for …
Lipodystrophic syndromes: from diagnosis to treatment
C Sollier, C Vatier, E Capel, O Lascols, M Auclair… - Annales d' …, 2020 - Elsevier
Lipodystrophic syndromes are acquired or genetic rare diseases, characterised by a
generalised or partial lack of adipose tissue leading to metabolic alterations linked to strong …
generalised or partial lack of adipose tissue leading to metabolic alterations linked to strong …
Effect of leptin therapy on survival in generalized and partial lipodystrophy: a matched cohort analysis
K Cook, O Ali, B Akinci… - The Journal of …, 2021 - academic.oup.com
Context Data quantifying the impact of metreleptin therapy on survival in non-human
immunodeficiency virus (HIV)-related generalized lipodystrophy (GL) and partial …
immunodeficiency virus (HIV)-related generalized lipodystrophy (GL) and partial …
The cutting edge: the role of mTOR signaling in laminopathies
F Chiarini, C Evangelisti, V Cenni, A Fazio… - International journal of …, 2019 - mdpi.com
The mechanistic target of rapamycin (mTOR) is a ubiquitous serine/threonine kinase that
regulates anabolic and catabolic processes, in response to environmental inputs. The …
regulates anabolic and catabolic processes, in response to environmental inputs. The …
Characterization of cytoplasmic lipid droplets in each region of the small intestine of lean and diet-induced obese mice in response to dietary fat
AS Zembroski, T D'Aquila… - American Journal of …, 2021 - journals.physiology.org
The absorptive cells of the small intestine, namely, enterocytes, contribute to postprandial
blood lipid levels by secreting dietary triacylglycerol in chylomicrons. The rate and amount of …
blood lipid levels by secreting dietary triacylglycerol in chylomicrons. The rate and amount of …