The tumor microenvironment (TME) is composed of many different cellular and acellular
components that together drive tumor growth, invasion, metastasis, and response to …

For decades, preclinical toxicology was essentially a descriptive discipline in which
treatment-related effects were carefully reported and used as a basis to calculate safety …

Abstract Dual Bcl-2/Bcl-xL inhibitors are expected to deliver therapeutic benefit in many
haematological and solid malignancies, however, their use is limited by tolerability issues …

Matrix-assisted laser desorption and ionization (MALDI) mass spectrometry (MS) is an
indispensable tool in modern lipid research since it is fast, sensitive, tolerates sample …

Mass spectrometry imaging is a technique uniquely suited to localize and identify lipids in a
tissue sample. Using an atmospheric pressure (AP-) matrix-assisted laser desorption …

The emerging and powerful field of spatial pharmacology can map the spatial distribution of
drugs and their metabolites, as well as their effects on endogenous biomolecules including …

Mass spectrometry imaging (MSI) techniques generate data that reveal spatial distributions
of molecules on a surface with high sensitivity and selectivity. However, processing large …

Herein, we assess the complementarity and complexity of data that can be detected within
mammalian lipidome mass spectrometry imaging (MSI) via matrix-assisted laser desorption …

Gemcitabine (dFdC) is a common treatment for pancreatic cancer; however, it is thought that
treatment may fail because tumor stroma prevents drug distribution to tumor cells …

Most mass spectrometry imaging (MSI) methods provide a molecular map of tissue content
but little information on tissue function. Mapping tissue function is possible using several …