Although covalent inhibitors have been used as therapeutics for more than a century, there
has been general resistance in the pharmaceutical industry against their further …

Cyclin-dependent kinase 2 (CDK2) drives the progression of cells into the S-and M-phases
of the cell cycle. CDK2 activity is largely dispensable for normal development, but it is …

In the hit identification stage of drug discovery, a diverse chemical space needs to be
explored to identify initial hits. Contrary to empirical scoring functions, absolute protein …

Motivation: Homology models of proteins are of great interest for planning and analysing
biological experiments when no experimental three-dimensional structures are available …

Cyclin-dependent kinases (CDK/Cyclins) form a family of heterodimeric kinases that play
central roles in regulation of cell cycle progression, transcription and other major biological …

The cell cycle is controlled by numerous mechanisms ensuring correct cell division. This
review will focus on these mechanisms, ie regulation of cyclin‐dependent kinases (CDK) by …

PD 0332991 is a highly specific inhibitor of cyclin-dependent kinase 4 (Cdk4)(IC50, 0.011
μmol/L) and Cdk6 (IC50, 0.016 μmol/L), having no activity against a panel of 36 additional …

Cell proliferation is an essential mechanism for growth, development and regeneration of
eukaryotic organisms; however, it is also the cause of one of the most devastating diseases …

Protein kinases are targets for treatment of a number of diseases. This review focuses on
kinase inhibitors that are in the clinic or in clinical trials and for which structural information is …

Cyclin-dependent kinases (cdks) are critical regulators of cell cycle progression and RNA
transcription. A variety of genetic and epigenetic events cause universal overactivity of the …