STUDY QUESTION Do mitochondria-targeted therapies reverse ageing-and oxidative stress-
induced spindle defects in oocytes from mice and humans? SUMMARY ANSWER Exposure …

Maternal obesity in humans is associated with poor outcomes across the reproductive
spectrum. Emerging evidence indicates that these defects are likely attributed to factors …

It is well established that age-related decline of the biological capacity of a woman to
reproduce is primarily related to the poor developmental potential of her gametes. This …

Producing high-competent oocytes during the in vitro maturation (IVM) is considered a key
step for the success of the in vitro production (IVP) of embryos. One of the known disruptors …

The oocyte requires a vast supply of energy after fertilization to support critical events such
as spindle formation, chromatid separation, and cell division. Until blastocyst implantation …

Ovarian aging is a natural and physiological aging process characterized by loss of quantity
and quality of oocyte or follicular pool. As it is generally accepted that women are born with a …

In the efforts aimed at improving the quality of in-vitro-matured human oocytes, the dynamic
balance and roles of pro-/antioxidants merit further consideration. In-vitromaturation (IVM) is …

Normal levels of reactive oxygen species (ROS) play an important role in regulating follicular
growth, angiogenesis and sex hormone synthesis in ovarian tissue. When the balance …

Increasing evidence shows that melatonin protected against age-related mitochondrial
oxidative damage. However, the protective effects of melatonin against ovarian aging has …

Obesity, diabetes, and related metabolic disorders are major health issues worldwide. As
the epidemic of metabolic disorders continues, the associated medical co-morbidities …